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Vaccination with a structure-based stabilized version of malarial antigen Pfs48/45 elicits ultra-potent transmission-blocking antibody responses.
McLeod B, Mabrouk MT, Miura K, Ravichandran R, Kephart S, Hailemariam S, Pham TP, Semesi A, Kucharska I, Kundu P, Huang WC, Johnson M, Blackstone A, Pettie D, Murphy M, Kraft JC, Leaf EM, Jiao Y, van de Vegte-Bolmer M, van Gemert GJ, Ramjith J, King CR, MacGill RS, Wu Y, Lee KK, Jore MM, King NP, Lovell JF, Julien JP. McLeod B, et al. Among authors: wu y. Immunity. 2022 Sep 13;55(9):1680-1692.e8. doi: 10.1016/j.immuni.2022.07.015. Epub 2022 Aug 16. Immunity. 2022. PMID: 35977542 Free PMC article.
Sustained high-titer antibody responses induced by conjugating a malarial vaccine candidate to outer-membrane protein complex.
Wu Y, Przysiecki C, Flanagan E, Bello-Irizarry SN, Ionescu R, Muratova O, Dobrescu G, Lambert L, Keister D, Rippeon Y, Long CA, Shi L, Caulfield M, Shaw A, Saul A, Shiver J, Miller LH. Wu Y, et al. Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18243-8. doi: 10.1073/pnas.0608545103. Epub 2006 Nov 16. Proc Natl Acad Sci U S A. 2006. PMID: 17110440 Free PMC article.
Phase 1 trial of malaria transmission blocking vaccine candidates Pfs25 and Pvs25 formulated with montanide ISA 51.
Wu Y, Ellis RD, Shaffer D, Fontes E, Malkin EM, Mahanty S, Fay MP, Narum D, Rausch K, Miles AP, Aebig J, Orcutt A, Muratova O, Song G, Lambert L, Zhu D, Miura K, Long C, Saul A, Miller LH, Durbin AP. Wu Y, et al. PLoS One. 2008 Jul 9;3(7):e2636. doi: 10.1371/journal.pone.0002636. PLoS One. 2008. PMID: 18612426 Free PMC article. Clinical Trial.
Enhanced antibody responses to Plasmodium falciparum Pfs28 induced in mice by conjugation to ExoProtein A of Pseudomonas aeruginosa with an improved procedure.
Qian F, Aebig JA, Reiter K, Barnafo E, Zhang Y, Shimp RL Jr, Rausch KM, Jones DS, Zhu D, Lambert L, Mullen GE, Narum DL, Miller LH, Wu Y. Qian F, et al. Among authors: wu y. Microbes Infect. 2009 Mar;11(3):408-12. doi: 10.1016/j.micinf.2008.12.009. Epub 2008 Dec 27. Microbes Infect. 2009. PMID: 19146977 Free PMC article.
Antibodies to plant-produced Plasmodium falciparum sexual stage protein Pfs25 exhibit transmission blocking activity.
Farrance CE, Chichester JA, Musiychuk K, Shamloul M, Rhee A, Manceva SD, Jones RM, Mamedov T, Sharma S, Mett V, Streatfield SJ, Roeffen W, van de Vegte-Bolmer M, Sauerwein RW, Wu Y, Muratova O, Miller L, Duffy P, Sinden R, Yusibov V. Farrance CE, et al. Among authors: wu y. Hum Vaccin. 2011 Jan-Feb;7 Suppl:191-8. doi: 10.4161/hv.7.0.14588. Epub 2011 Jan 1. Hum Vaccin. 2011. PMID: 21266847
A plant-produced Pfs230 vaccine candidate blocks transmission of Plasmodium falciparum.
Farrance CE, Rhee A, Jones RM, Musiychuk K, Shamloul M, Sharma S, Mett V, Chichester JA, Streatfield SJ, Roeffen W, van de Vegte-Bolmer M, Sauerwein RW, Tsuboi T, Muratova OV, Wu Y, Yusibov V. Farrance CE, et al. Among authors: wu y. Clin Vaccine Immunol. 2011 Aug;18(8):1351-7. doi: 10.1128/CVI.05105-11. Epub 2011 Jun 29. Clin Vaccine Immunol. 2011. PMID: 21715576 Free PMC article.
A class of tricyclic compounds blocking malaria parasite oocyst development and transmission.
Eastman RT, Pattaradilokrat S, Raj DK, Dixit S, Deng B, Miura K, Yuan J, Tanaka TQ, Johnson RL, Jiang H, Huang R, Williamson KC, Lambert LE, Long C, Austin CP, Wu Y, Su XZ. Eastman RT, et al. Among authors: wu y. Antimicrob Agents Chemother. 2013 Jan;57(1):425-35. doi: 10.1128/AAC.00920-12. Epub 2012 Nov 5. Antimicrob Agents Chemother. 2013. PMID: 23129054 Free PMC article.
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