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POU2F3 is a master regulator of a tuft cell-like variant of small cell lung cancer.
Huang YH, Klingbeil O, He XY, Wu XS, Arun G, Lu B, Somerville TDD, Milazzo JP, Wilkinson JE, Demerdash OE, Spector DL, Egeblad M, Shi J, Vakoc CR. Huang YH, et al. Among authors: wu xs. Genes Dev. 2018 Jul 1;32(13-14):915-928. doi: 10.1101/gad.314815.118. Epub 2018 Jun 26. Genes Dev. 2018. PMID: 29945888 Free PMC article.
A Transcription Factor Addiction in Leukemia Imposed by the MLL Promoter Sequence.
Lu B, Klingbeil O, Tarumoto Y, Somerville TDD, Huang YH, Wei Y, Wai DC, Low JKK, Milazzo JP, Wu XS, Cao Z, Yan X, Demerdash OE, Huang G, Mackay JP, Kinney JB, Shi J, Vakoc CR. Lu B, et al. Among authors: wu xs. Cancer Cell. 2018 Dec 10;34(6):970-981.e8. doi: 10.1016/j.ccell.2018.10.015. Epub 2018 Nov 29. Cancer Cell. 2018. PMID: 30503706 Free PMC article.
The E3 ligase adaptor molecule SPOP regulates fetal hemoglobin levels in adult erythroid cells.
Lan X, Khandros E, Huang P, Peslak SA, Bhardwaj SK, Grevet JD, Abdulmalik O, Wang H, Keller CA, Giardine B, Baeza J, Duffner ER, El Demerdash O, Wu XS, Vakoc CR, Garcia BA, Hardison RC, Shi J, Blobel GA. Lan X, et al. Among authors: wu xs. Blood Adv. 2019 May 28;3(10):1586-1597. doi: 10.1182/bloodadvances.2019032318. Blood Adv. 2019. PMID: 31126914 Free PMC article.
Histone hyperacetylation disrupts core gene regulatory architecture in rhabdomyosarcoma.
Gryder BE, Pomella S, Sayers C, Wu XS, Song Y, Chiarella AM, Bagchi S, Chou HC, Sinniah RS, Walton A, Wen X, Rota R, Hathaway NA, Zhao K, Chen J, Vakoc CR, Shern JF, Stanton BZ, Khan J. Gryder BE, et al. Among authors: wu xs. Nat Genet. 2019 Dec;51(12):1714-1722. doi: 10.1038/s41588-019-0534-4. Epub 2019 Nov 29. Nat Genet. 2019. PMID: 31784732 Free PMC article.
A pliable ERα cistrome evades therapy.
Wu XS, Vakoc CR. Wu XS, et al. Nat Cell Biol. 2020 Jun;22(6):619-620. doi: 10.1038/s41556-020-0528-6. Nat Cell Biol. 2020. PMID: 32424274 No abstract available.
Transcriptional Silencing of ALDH2 Confers a Dependency on Fanconi Anemia Proteins in Acute Myeloid Leukemia.
Yang Z, Wu XS, Wei Y, Polyanskaya SA, Iyer SV, Jung M, Lach FP, Adelman ER, Klingbeil O, Milazzo JP, Kramer M, Demerdash OE, Chang K, Goodwin S, Hodges E, McCombie WR, Figueroa ME, Smogorzewska A, Vakoc CR. Yang Z, et al. Among authors: wu xs. Cancer Discov. 2021 Sep;11(9):2300-2315. doi: 10.1158/2159-8290.CD-20-1542. Epub 2021 Apr 23. Cancer Discov. 2021. PMID: 33893150 Free PMC article.
BAF complexes drive proliferation and block myogenic differentiation in fusion-positive rhabdomyosarcoma.
Laubscher D, Gryder BE, Sunkel BD, Andresson T, Wachtel M, Das S, Roschitzki B, Wolski W, Wu XS, Chou HC, Song YK, Wang C, Wei JS, Wang M, Wen X, Ngo QA, Marques JG, Vakoc CR, Schäfer BW, Stanton BZ, Khan J. Laubscher D, et al. Among authors: wu xs. Nat Commun. 2021 Nov 26;12(1):6924. doi: 10.1038/s41467-021-27176-w. Nat Commun. 2021. PMID: 34836971 Free PMC article.
OCA-T1 and OCA-T2 are coactivators of POU2F3 in the tuft cell lineage.
Wu XS, He XY, Ipsaro JJ, Huang YH, Preall JB, Ng D, Shue YT, Sage J, Egeblad M, Joshua-Tor L, Vakoc CR. Wu XS, et al. Nature. 2022 Jul;607(7917):169-175. doi: 10.1038/s41586-022-04842-7. Epub 2022 May 16. Nature. 2022. PMID: 35576971 Free PMC article.
397 results