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Progesterone activates GPR126 to promote breast cancer development via the Gi pathway.
An W, Lin H, Ma L, Zhang C, Zheng Y, Cheng Q, Ma C, Wu X, Zhang Z, Zhong Y, Wang M, He D, Yang Z, Du L, Feng S, Wang C, Yang F, Xiao P, Zhang P, Yu X, Sun JP. An W, et al. Among authors: wu x. Proc Natl Acad Sci U S A. 2022 Apr 12;119(15):e2117004119. doi: 10.1073/pnas.2117004119. Epub 2022 Apr 8. Proc Natl Acad Sci U S A. 2022. PMID: 35394864 Free PMC article.
Structural basis and molecular mechanism of biased GPBAR signaling in regulating NSCLC cell growth via YAP activity.
Ma L, Yang F, Wu X, Mao C, Guo L, Miao T, Zang SK, Jiang X, Shen DD, Wei T, Zhou H, Wei Q, Li S, Shu Q, Feng S, Jiang C, Chu B, Du L, Sun JP, Yu X, Zhang Y, Zhang P. Ma L, et al. Among authors: wu x. Proc Natl Acad Sci U S A. 2022 Jul 19;119(29):e2117054119. doi: 10.1073/pnas.2117054119. Epub 2022 Jul 15. Proc Natl Acad Sci U S A. 2022. PMID: 35858343 Free PMC article.
Structural basis for the tethered peptide activation of adhesion GPCRs.
Ping YQ, Xiao P, Yang F, Zhao RJ, Guo SC, Yan X, Wu X, Zhang C, Lu Y, Zhao F, Zhou F, Xi YT, Yin W, Liu FZ, He DF, Zhang DL, Zhu ZL, Jiang Y, Du L, Feng SQ, Schöneberg T, Liebscher I, Xu HE, Sun JP. Ping YQ, et al. Among authors: wu x. Nature. 2022 Apr;604(7907):763-770. doi: 10.1038/s41586-022-04619-y. Epub 2022 Apr 13. Nature. 2022. PMID: 35418678
Structural basis of GPBAR activation and bile acid recognition.
Yang F, Mao C, Guo L, Lin J, Ming Q, Xiao P, Wu X, Shen Q, Guo S, Shen DD, Lu R, Zhang L, Huang S, Ping Y, Zhang C, Ma C, Zhang K, Liang X, Shen Y, Nan F, Yi F, Luca VC, Zhou J, Jiang C, Sun JP, Xie X, Yu X, Zhang Y. Yang F, et al. Among authors: wu x. Nature. 2020 Nov;587(7834):499-504. doi: 10.1038/s41586-020-2569-1. Epub 2020 Jul 22. Nature. 2020. PMID: 32698187
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