Wu L - Search Results

1

Structural and mechanistic characterization of bifunctional heparan sulfate N-deacetylase-N-sulfotransferase 1.

Mycroft-West CJ, Abdelkarim S, Duyvesteyn HME, Gandhi NS, Skidmore MA, Owens RJ, Wu L. Mycroft-West CJ, et al. Among authors: wu l. Nat Commun. 2024 Feb 13;15(1):1326. doi: 10.1038/s41467-024-45419-4. Nat Commun. 2024. PMID: 38351061 Free PMC article.

2

Structural Insights into Pixatimod (PG545) Inhibition of Heparanase, a Key Enzyme in Cancer and Viral Infections.

Chhabra M, Wilson JC, Wu L, Davies GJ, Gandhi NS, Ferro V. Chhabra M, et al. Among authors: wu l. Chemistry. 2022 Feb 19;28(11):e202104222. doi: 10.1002/chem.202104222. Epub 2022 Jan 31. Chemistry. 2022. PMID: 34981584 Free PMC article.

3

Structural characterization of human heparanase reveals insights into substrate recognition.

Wu L, Viola CM, Brzozowski AM, Davies GJ. Wu L, et al. Nat Struct Mol Biol. 2015 Dec;22(12):1016-22. doi: 10.1038/nsmb.3136. Epub 2015 Nov 16. Nat Struct Mol Biol. 2015. PMID: 26575439 Free PMC article.

4

Structural insights into heparanase activity using a fluorogenic heparan sulfate disaccharide.

Wu L, Wimmer N, Davies GJ, Ferro V. Wu L, et al. Chem Commun (Camb). 2020 Nov 10;56(89):13780-13783. doi: 10.1039/d0cc05932c. Chem Commun (Camb). 2020. PMID: 33073275

5

An Overview of the Structure, Mechanism and Specificity of Human Heparanase.

Wu L, Davies GJ. Wu L, et al. Adv Exp Med Biol. 2020;1221:139-167. doi: 10.1007/978-3-030-34521-1_5. Adv Exp Med Biol. 2020. PMID: 32274709 Review.

6

Cryo-EM structures of human fucosidase FucA1 reveal insight into substrate recognition and catalysis.

Armstrong Z, Meek RW, Wu L, Blaza JN, Davies GJ. Armstrong Z, et al. Among authors: wu l. Structure. 2022 Oct 6;30(10):1443-1451.e5. doi: 10.1016/j.str.2022.07.001. Epub 2022 Jul 29. Structure. 2022. PMID: 35907402 Free PMC article.

7

Inverting family GH156 sialidases define an unusual catalytic motif for glycosidase action.

Bule P, Chuzel L, Blagova E, Wu L, Gray MA, Henrissat B, Rapp E, Bertozzi CR, Taron CH, Davies GJ. Bule P, et al. Among authors: wu l. Nat Commun. 2019 Oct 23;10(1):4816. doi: 10.1038/s41467-019-12684-7. Nat Commun. 2019. PMID: 31645552 Free PMC article.

8

Mechanism-based heparanase inhibitors reduce cancer metastasis in vivo.

de Boer C, Armstrong Z, Lit VAJ, Barash U, Ruijgrok G, Boyango I, Weitzenberg MM, Schröder SP, Sarris AJC, Meeuwenoord NJ, Bule P, Kayal Y, Ilan N, Codée JDC, Vlodavsky I, Overkleeft HS, Davies GJ, Wu L. de Boer C, et al. Among authors: wu l. Proc Natl Acad Sci U S A. 2022 Aug 2;119(31):e2203167119. doi: 10.1073/pnas.2203167119. Epub 2022 Jul 26. Proc Natl Acad Sci U S A. 2022. PMID: 35881786 Free PMC article.

9

Design, Synthesis and Structural Analysis of Glucocerebrosidase Imaging Agents.

Rowland RJ, Chen Y, Breen I, Wu L, Offen WA, Beenakker TJ, Su Q, van den Nieuwendijk AMCH, Aerts JMFG, Artola M, Overkleeft HS, Davies GJ. Rowland RJ, et al. Among authors: wu l. Chemistry. 2021 Nov 25;27(66):16377-16388. doi: 10.1002/chem.202102359. Epub 2021 Oct 29. Chemistry. 2021. PMID: 34570911 Free PMC article.

10

Activity-based probes for functional interrogation of retaining β-glucuronidases.

Wu L, Jiang J, Jin Y, Kallemeijn WW, Kuo CL, Artola M, Dai W, van Elk C, van Eijk M, van der Marel GA, Codée JDC, Florea BI, Aerts JMFG, Overkleeft HS, Davies GJ. Wu L, et al. Nat Chem Biol. 2017 Aug;13(8):867-873. doi: 10.1038/nchembio.2395. Epub 2017 Jun 5. Nat Chem Biol. 2017. PMID: 28581485 Free article.

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