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Inhibition of ATP-citrate lyase improves NASH, liver fibrosis, and dyslipidemia.
Morrow MR, Batchuluun B, Wu J, Ahmadi E, Leroux JM, Mohammadi-Shemirani P, Desjardins EM, Wang Z, Tsakiridis EE, Lavoie DCT, Reihani A, Smith BK, Kwiecien JM, Lally JSV, Nero TL, Parker MW, Ask K, Scott JW, Jiang L, Paré G, Pinkosky SL, Steinberg GR. Morrow MR, et al. Among authors: wu j. Cell Metab. 2022 Jun 7;34(6):919-936.e8. doi: 10.1016/j.cmet.2022.05.004. Cell Metab. 2022. PMID: 35675800 Free article.
The pesticide chlorpyrifos promotes obesity by inhibiting diet-induced thermogenesis in brown adipose tissue.
Wang B, Tsakiridis EE, Zhang S, Llanos A, Desjardins EM, Yabut JM, Green AE, Day EA, Smith BK, Lally JSV, Wu J, Raphenya AR, Srinivasan KA, McArthur AG, Kajimura S, Patel JS, Wade MG, Morrison KM, Holloway AC, Steinberg GR. Wang B, et al. Among authors: wu j. Nat Commun. 2021 Aug 27;12(1):5163. doi: 10.1038/s41467-021-25384-y. Nat Commun. 2021. PMID: 34453052 Free PMC article.
Metformin-induced reductions in tumor growth involves modulation of the gut microbiome.
Broadfield LA, Saigal A, Szamosi JC, Hammill JA, Bezverbnaya K, Wang D, Gautam J, Tsakiridis EE, Di Pastena F, McNicol J, Wu J, Syed S, Lally JSV, Raphenya AR, Blouin MJ, Pollak M, Sacconi A, Blandino G, McArthur AG, Schertzer JD, Surette MG, Collins SM, Bramson JL, Muti P, Tsakiridis T, Steinberg GR. Broadfield LA, et al. Among authors: wu j. Mol Metab. 2022 Jul;61:101498. doi: 10.1016/j.molmet.2022.101498. Epub 2022 Apr 20. Mol Metab. 2022. PMID: 35452877 Free PMC article.
Canagliflozin mediates tumor suppression alone and in combination with radiotherapy in non-small cell lung cancer (NSCLC) through inhibition of HIF-1α.
Biziotis OD, Tsakiridis EE, Ali A, Ahmadi E, Wu J, Wang S, Mekhaeil B, Singh K, Menjolian G, Farrell T, Abdulkarim B, Sur RK, Mesci A, Ellis P, Berg T, Bramson JL, Muti P, Steinberg GR, Tsakiridis T. Biziotis OD, et al. Among authors: wu j. Mol Oncol. 2023 Nov;17(11):2235-2256. doi: 10.1002/1878-0261.13508. Epub 2023 Aug 27. Mol Oncol. 2023. PMID: 37584455 Free PMC article.
Combination of an ACLY inhibitor with a GLP-1R agonist exerts additive benefits on nonalcoholic steatohepatitis and hepatic fibrosis in mice.
Desjardins EM, Wu J, Lavoie DCT, Ahmadi E, Townsend LK, Morrow MR, Wang D, Tsakiridis EE, Batchuluun B, Fayyazi R, Kwiecien JM, Tsakiridis T, Lally JSV, Paré G, Pinkosky SL, Steinberg GR. Desjardins EM, et al. Among authors: wu j. Cell Rep Med. 2023 Sep 19;4(9):101193. doi: 10.1016/j.xcrm.2023.101193. Cell Rep Med. 2023. PMID: 37729871 Free PMC article.
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