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Peptide-based covalent inhibitors of MALT1 paracaspase.
Hatcher JM, Du G, Fontán L, Us I, Qiao Q, Chennamadhavuni S, Shao J, Wu H, Melnick A, Gray NS, Scott DA. Hatcher JM, et al. Among authors: wu h. Bioorg Med Chem Lett. 2019 Jun 1;29(11):1336-1339. doi: 10.1016/j.bmcl.2019.03.046. Epub 2019 Mar 29. Bioorg Med Chem Lett. 2019. PMID: 30954428
MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivo.
Fontan L, Yang C, Kabaleeswaran V, Volpon L, Osborne MJ, Beltran E, Garcia M, Cerchietti L, Shaknovich R, Yang SN, Fang F, Gascoyne RD, Martinez-Climent JA, Glickman JF, Borden K, Wu H, Melnick A. Fontan L, et al. Among authors: wu h. Cancer Cell. 2012 Dec 11;22(6):812-24. doi: 10.1016/j.ccr.2012.11.003. Cancer Cell. 2012. PMID: 23238016 Free PMC article.
Ruxolitinib reverses dysregulated T helper cell responses and controls autoimmunity caused by a novel signal transducer and activator of transcription 1 (STAT1) gain-of-function mutation.
Weinacht KG, Charbonnier LM, Alroqi F, Plant A, Qiao Q, Wu H, Ma C, Torgerson TR, Rosenzweig SD, Fleisher TA, Notarangelo LD, Hanson IC, Forbes LR, Chatila TA. Weinacht KG, et al. Among authors: wu h. J Allergy Clin Immunol. 2017 May;139(5):1629-1640.e2. doi: 10.1016/j.jaci.2016.11.022. Epub 2017 Jan 27. J Allergy Clin Immunol. 2017. PMID: 28139313 Free PMC article.
Understanding CARD Tricks in Apoptosomes.
Wang L, Qiao Q, Wu H. Wang L, et al. Among authors: wu h. Structure. 2017 Apr 4;25(4):575-577. doi: 10.1016/j.str.2017.03.013. Structure. 2017. PMID: 28380338 Free PMC article.
AID Recognizes Structured DNA for Class Switch Recombination.
Qiao Q, Wang L, Meng FL, Hwang JK, Alt FW, Wu H. Qiao Q, et al. Among authors: wu h. Mol Cell. 2017 Aug 3;67(3):361-373.e4. doi: 10.1016/j.molcel.2017.06.034. Epub 2017 Jul 27. Mol Cell. 2017. PMID: 28757211 Free PMC article.
Crystal structure of human IRAK1.
Wang L, Qiao Q, Ferrao R, Shen C, Hatcher JM, Buhrlage SJ, Gray NS, Wu H. Wang L, et al. Among authors: wu h. Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):13507-13512. doi: 10.1073/pnas.1714386114. Epub 2017 Dec 5. Proc Natl Acad Sci U S A. 2017. PMID: 29208712 Free PMC article.
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