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SARS-CoV-2 infects human pancreatic β cells and elicits β cell impairment.
Wu CT, Lidsky PV, Xiao Y, Lee IT, Cheng R, Nakayama T, Jiang S, Demeter J, Bevacqua RJ, Chang CA, Whitener RL, Stalder AK, Zhu B, Chen H, Goltsev Y, Tzankov A, Nayak JV, Nolan GP, Matter MS, Andino R, Jackson PK. Wu CT, et al. Cell Metab. 2021 Aug 3;33(8):1565-1576.e5. doi: 10.1016/j.cmet.2021.05.013. Epub 2021 May 18. Cell Metab. 2021. PMID: 34081912 Free PMC article.
Robust ACE2 protein expression localizes to the motile cilia of the respiratory tract epithelia and is not increased by ACE inhibitors or angiotensin receptor blockers.
Lee IT, Nakayama T, Wu CT, Goltsev Y, Jiang S, Gall PA, Liao CK, Shih LC, Schürch CM, McIlwain DR, Chu P, Borchard NA, Zarabanda D, Dholakia SS, Yang A, Kim D, Kanie T, Lin CD, Tsai MH, Phillips KM, Kim R, Overdevest JB, Tyler MA, Yan CH, Lin CF, Lin YT, Bau DT, Tsay GJ, Patel ZM, Tsou YA, Tai CJ, Yeh TH, Hwang PH, Nolan GP, Nayak JV, Jackson PK. Lee IT, et al. Among authors: wu ct. medRxiv [Preprint]. 2020 May 12:2020.05.08.20092866. doi: 10.1101/2020.05.08.20092866. medRxiv. 2020. PMID: 32511516 Free PMC article. Updated. Preprint.
ACE2 localizes to the respiratory cilia and is not increased by ACE inhibitors or ARBs.
Lee IT, Nakayama T, Wu CT, Goltsev Y, Jiang S, Gall PA, Liao CK, Shih LC, Schürch CM, McIlwain DR, Chu P, Borchard NA, Zarabanda D, Dholakia SS, Yang A, Kim D, Chen H, Kanie T, Lin CD, Tsai MH, Phillips KM, Kim R, Overdevest JB, Tyler MA, Yan CH, Lin CF, Lin YT, Bau DT, Tsay GJ, Patel ZM, Tsou YA, Tzankov A, Matter MS, Tai CJ, Yeh TH, Hwang PH, Nolan GP, Nayak JV, Jackson PK. Lee IT, et al. Among authors: wu ct. Nat Commun. 2020 Oct 28;11(1):5453. doi: 10.1038/s41467-020-19145-6. Nat Commun. 2020. PMID: 33116139 Free PMC article.
Ethacridine inhibits SARS-CoV-2 by inactivating viral particles.
Li X, Lidsky PV, Xiao Y, Wu CT, Garcia-Knight M, Yang J, Nakayama T, Nayak JV, Jackson PK, Andino R, Shu X. Li X, et al. Among authors: wu ct. PLoS Pathog. 2021 Sep 3;17(9):e1009898. doi: 10.1371/journal.ppat.1009898. eCollection 2021 Sep. PLoS Pathog. 2021. PMID: 34478458 Free PMC article.
Determinants of SARS-CoV-2 entry and replication in airway mucosal tissue and susceptibility in smokers.
Nakayama T, Lee IT, Jiang S, Matter MS, Yan CH, Overdevest JB, Wu CT, Goltsev Y, Shih LC, Liao CK, Zhu B, Bai Y, Lidsky P, Xiao Y, Zarabanda D, Yang A, Easwaran M, Schürch CM, Chu P, Chen H, Stalder AK, McIlwain DR, Borchard NA, Gall PA, Dholakia SS, Le W, Xu L, Tai CJ, Yeh TH, Erickson-Direnzo E, Duran JM, Mertz KD, Hwang PH, Haslbauer JD, Jackson PK, Menter T, Andino R, Canoll PD, DeConde AS, Patel ZM, Tzankov A, Nolan GP, Nayak JV. Nakayama T, et al. Among authors: wu ct. Cell Rep Med. 2021 Oct 19;2(10):100421. doi: 10.1016/j.xcrm.2021.100421. Epub 2021 Sep 28. Cell Rep Med. 2021. PMID: 34604819 Free PMC article.
A defective viral genome strategy elicits broad protective immunity against respiratory viruses.
Xiao Y, Lidsky PV, Shirogane Y, Aviner R, Wu CT, Li W, Zheng W, Talbot D, Catching A, Doitsh G, Su W, Gekko CE, Nayak A, Ernst JD, Brodsky L, Brodsky E, Rousseau E, Capponi S, Bianco S, Nakamura R, Jackson PK, Frydman J, Andino R. Xiao Y, et al. Among authors: wu ct. Cell. 2021 Dec 9;184(25):6037-6051.e14. doi: 10.1016/j.cell.2021.11.023. Epub 2021 Nov 18. Cell. 2021. PMID: 34852237 Free PMC article.
SARS-CoV-2 replication in airway epithelia requires motile cilia and microvillar reprogramming.
Wu CT, Lidsky PV, Xiao Y, Cheng R, Lee IT, Nakayama T, Jiang S, He W, Demeter J, Knight MG, Turn RE, Rojas-Hernandez LS, Ye C, Chiem K, Shon J, Martinez-Sobrido L, Bertozzi CR, Nolan GP, Nayak JV, Milla C, Andino R, Jackson PK. Wu CT, et al. Cell. 2023 Jan 5;186(1):112-130.e20. doi: 10.1016/j.cell.2022.11.030. Epub 2022 Dec 2. Cell. 2023. PMID: 36580912 Free PMC article.
Fluorogenic reporter enables identification of compounds that inhibit SARS-CoV-2.
Yang J, Xiao Y, Lidsky PV, Wu CT, Bonser LR, Peng S, Garcia-Knight MA, Tassetto M, Chung CI, Li X, Nakayama T, Lee IT, Nayak JV, Ghias K, Hargett KL, Shoichet BK, Erle DJ, Jackson PK, Andino R, Shu X. Yang J, et al. Among authors: wu ct. Nat Microbiol. 2023 Jan;8(1):121-134. doi: 10.1038/s41564-022-01288-5. Epub 2023 Jan 5. Nat Microbiol. 2023. PMID: 36604514 Free PMC article.
1,259 results