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Novel multi-target ligands of dopamine and serotonin receptors for the treatment of schizophrenia based on indazole and piperazine scaffolds-synthesis, biological activity, and structural evaluation.
Stępnicki P, Wronikowska-Denysiuk O, Zięba A, Targowska-Duda KM, Bartyzel A, Wróbel MZ, Wróbel TM, Szałaj K, Chodkowski A, Mirecka K, Budzyńska B, Fornal E, Turło J, Castro M, Kaczor AA. Stępnicki P, et al. Among authors: wrobel mz. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2209828. doi: 10.1080/14756366.2023.2209828. J Enzyme Inhib Med Chem. 2023. PMID: 37184096 Free PMC article.
Synthesis and biological evaluation of novel pyrrolidine-2,5-dione derivatives as potential antidepressant agents. Part 1.
Wróbel MZ, Chodkowski A, Herold F, Gomółka A, Kleps J, Mazurek AP, Pluciński F, Mazurek A, Nowak G, Siwek A, Stachowicz K, Sławińska A, Wolak M, Szewczyk B, Satała G, Bojarski AJ, Turło J. Wróbel MZ, et al. Eur J Med Chem. 2013 May;63:484-500. doi: 10.1016/j.ejmech.2013.02.033. Epub 2013 Mar 5. Eur J Med Chem. 2013. PMID: 23524160
Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT(1A) activity. Part 5.
Gomółka A, Ciesielska A, Wróbel MZ, Chodkowski A, Kleps J, Dawidowski M, Siwek A, Wolak M, Stachowicz K, Sławińska A, Nowak G, Satała G, Bojarski AJ, Belka M, Ulenberg S, Bączek T, Skowronek P, Turło J, Herold F. Gomółka A, et al. Among authors: wrobel mz. Eur J Med Chem. 2015 Jun 15;98:221-36. doi: 10.1016/j.ejmech.2015.05.003. Epub 2015 May 9. Eur J Med Chem. 2015. PMID: 26043160
Synthesis and biological investigation of new equatorial (β) stereoisomers of 3-aminotropane arylamides with atypical antipsychotic profile.
Stefanowicz J, Słowiński T, Wróbel MZ, Herold F, Gomółka AE, Wesołowska A, Jastrzębska-Więsek M, Partyka A, Andres-Mach M, Czuczwar SJ, Łuszczki JJ, Zagaja M, Siwek A, Nowak G, Żołnierek M, Bączek T, Ulenberg S, Belka M, Turło J. Stefanowicz J, et al. Among authors: wrobel mz. Bioorg Med Chem. 2016 Sep 15;24(18):3994-4007. doi: 10.1016/j.bmc.2016.06.038. Epub 2016 Jun 20. Bioorg Med Chem. 2016. PMID: 27377863
Synthesis and biological evaluation of new multi-target 3-(1H-indol-3-yl)pyrrolidine-2,5-dione derivatives with potential antidepressant effect.
Wróbel MZ, Chodkowski A, Herold F, Marciniak M, Dawidowski M, Siwek A, Starowicz G, Stachowicz K, Szewczyk B, Nowak G, Belka M, Bączek T, Satała G, Bojarski AJ, Turło J. Wróbel MZ, et al. Eur J Med Chem. 2019 Dec 1;183:111736. doi: 10.1016/j.ejmech.2019.111736. Epub 2019 Sep 26. Eur J Med Chem. 2019. PMID: 31586817 Free article.
Structure-activity relationship and cardiac safety of 2-aryl-2-(pyridin-2-yl)acetamides as a new class of broad-spectrum anticonvulsants derived from Disopyramide.
Dawidowski M, Król M, Szulczyk B, Chodkowski A, Podsadni P, Konopelski P, Ufnal M, Szuberski P, Wróbel MZ, Zhang Y, El Harchi A, Hancox JC, Jarkovska D, Mistrova E, Sviglerova J, Štengl M, Popowicz GM, Turło J. Dawidowski M, et al. Among authors: wrobel mz. Bioorg Chem. 2020 May;98:103717. doi: 10.1016/j.bioorg.2020.103717. Epub 2020 Mar 5. Bioorg Chem. 2020. PMID: 32171994 Free article.
14 results