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Biginelli Reaction Synthesis of Novel Multitarget-Directed Ligands with Ca2+ Channel Blocking Ability, Cholinesterase Inhibition, Antioxidant Capacity, and Nrf2 Activation.
Malek R, Simakov A, Davis A, Maj M, Bernard PJ, Wnorowski A, Martin H, Marco-Contelles J, Chabchoub F, Dallemagne P, Rochais C, Jozwiak K, Ismaili L. Malek R, et al. Among authors: wnorowski a. Molecules. 2022 Dec 22;28(1):71. doi: 10.3390/molecules28010071. Molecules. 2022. PMID: 36615267 Free PMC article.
Design, Synthesis and Biological Evaluation of New Antioxidant and Neuroprotective Multitarget Directed Ligands Able to Block Calcium Channels.
Pachòn Angona I, Daniel S, Martin H, Bonet A, Wnorowski A, Maj M, Jóźwiak K, Silva TB, Refouvelet B, Borges F, Marco-Contelles J, Ismaili L. Pachòn Angona I, et al. Among authors: wnorowski a. Molecules. 2020 Mar 14;25(6):1329. doi: 10.3390/molecules25061329. Molecules. 2020. PMID: 32183349 Free PMC article.
Tacripyrimidines, the first tacrine-dihydropyrimidine hybrids, as multi-target-directed ligands for Alzheimer's disease.
Chioua M, Buzzi E, Moraleda I, Iriepa I, Maj M, Wnorowski A, Giovannini C, Tramarin A, Portali F, Ismaili L, López-Alvarado P, Bolognesi ML, Jóźwiak K, Menéndez JC, Marco-Contelles J, Bartolini M. Chioua M, et al. Among authors: wnorowski a. Eur J Med Chem. 2018 Jul 15;155:839-846. doi: 10.1016/j.ejmech.2018.06.044. Epub 2018 Jun 19. Eur J Med Chem. 2018. PMID: 29958119
Type I and type II positive allosteric modulators of α7 nicotinic acetylcholine receptors induce antidepressant-like activity in mice by a mechanism involving receptor potentiation but not neurotransmitter reuptake inhibition. Correlation with mTOR intracellular pathway activation.
Targowska-Duda KM, Budzynska B, Michalak A, Wnorowski A, Loland CJ, Maj M, Manetti D, Romanelli MN, Jozwiak K, Biala G, Arias HR. Targowska-Duda KM, et al. Among authors: wnorowski a. Eur Neuropsychopharmacol. 2021 Nov;52:31-47. doi: 10.1016/j.euroneuro.2021.06.006. Epub 2021 Jul 6. Eur Neuropsychopharmacol. 2021. PMID: 34237657
91 results