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Thalidomide maintenance therapy maturates the T cell compartment and compromises antigen-specific antitumor immunity in patients with multiple myeloma.
Herth I, Witzens-Harig M, Beckhove P, Hose D, Meissner T, Neuber B, Engelhardt M, Haas J, Neben K, Ho AD, Klein B, Goldschmidt H, Hundemer M. Herth I, et al. Exp Hematol. 2013 Mar;41(3):231-40. doi: 10.1016/j.exphem.2012.10.018. Epub 2012 Nov 8. Exp Hematol. 2013. PMID: 23142220 Free article. Clinical Trial.
Tumor cells in multiple myeloma patients inhibit myeloma-reactive T cells through carcinoembryonic antigen-related cell adhesion molecule-6.
Witzens-Harig M, Hose D, Jünger S, Pfirschke C, Khandelwal N, Umansky L, Seckinger A, Conrad H, Brackertz B, Rème T, Gueckel B, Meißner T, Hundemer M, Ho AD, Rossi JF, Neben K, Bernhard H, Goldschmidt H, Klein B, Beckhove P. Witzens-Harig M, et al. Blood. 2013 May 30;121(22):4493-503. doi: 10.1182/blood-2012-05-429415. Epub 2013 Apr 19. Blood. 2013. PMID: 23603913 Free article.
Lenalidomide overcomes the immunosuppression of regulatory CD8+CD28- T-cells.
Neuber B, Dai J, Waraich WA, Awwad MHS, Engelhardt M, Schmitt M, Medenhoff S, Witzens-Harig M, Ho AD, Goldschmidt H, Hundemer M. Neuber B, et al. Oncotarget. 2017 Oct 5;8(58):98200-98214. doi: 10.18632/oncotarget.21516. eCollection 2017 Nov 17. Oncotarget. 2017. PMID: 29228683 Free PMC article.
Ibrutinib.
Charalambous A, Schwarzbich MA, Witzens-Harig M. Charalambous A, et al. Recent Results Cancer Res. 2018;212:133-168. doi: 10.1007/978-3-319-91439-8_7. Recent Results Cancer Res. 2018. PMID: 30069629
115 results