Witkin JM - Search Results

1

The imidazodiazepine, KRM-II-81: An example of a newly emerging generation of GABAkines for neurological and psychiatric disorders.

Witkin JM, Lippa A, Smith JL, Jin X, Ping X, Biggerstaff A, Kivell BM, Knutson DE, Sharmin D, Pandey KP, Mian MY, Cook JM, Cerne R. Witkin JM, et al. Pharmacol Biochem Behav. 2022 Feb;213:173321. doi: 10.1016/j.pbb.2021.173321. Epub 2022 Jan 15. Pharmacol Biochem Behav. 2022. PMID: 35041859 Review.

2

Differential antagonism of diazepam-induced loss of the righting response.

Witkin JM, Barrett JE, Cook JM, Larscheid P. Witkin JM, et al. Pharmacol Biochem Behav. 1986 Apr;24(4):963-5. doi: 10.1016/0091-3057(86)90443-0. Pharmacol Biochem Behav. 1986. PMID: 3012601

3

Perampanel, an antagonist of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors, for the treatment of epilepsy: studies in human epileptic brain and nonepileptic brain and in rodent models.

Zwart R, Sher E, Ping X, Jin X, Sims JR Jr, Chappell AS, Gleason SD, Hahn PJ, Gardinier K, Gernert DL, Hobbs J, Smith JL, Valli SN, Witkin JM. Zwart R, et al. Among authors: witkin jm. J Pharmacol Exp Ther. 2014 Oct;351(1):124-33. doi: 10.1124/jpet.114.212779. Epub 2014 Jul 15. J Pharmacol Exp Ther. 2014. PMID: 25027316

4

Synthesis and Characterization of a Novel γ-Aminobutyric Acid Type A (GABA_A) Receptor Ligand That Combines Outstanding Metabolic Stability, Pharmacokinetics, and Anxiolytic Efficacy.

Poe MM, Methuku KR, Li G, Verma AR, Teske KA, Stafford DC, Arnold LA, Cramer JW, Jones TM, Cerne R, Krambis MJ, Witkin JM, Jambrina E, Rehman S, Ernst M, Cook JM, Schkeryantz JM. Poe MM, et al. Among authors: witkin jm. J Med Chem. 2016 Dec 8;59(23):10800-10806. doi: 10.1021/acs.jmedchem.6b01332. Epub 2016 Nov 28. J Med Chem. 2016. PMID: 27933953 Free PMC article.

5

Further evaluation of the potential anxiolytic activity of imidazo[1,5-a][1,4]diazepin agents selective for α2/3-containing GABA_A receptors.

Witkin JM, Cerne R, Wakulchik M, S J, Gleason SD, Jones TM, Li G, Arnold LA, Li JX, Schkeryantz JM, Methuku KR, Cook JM, Poe MM. Witkin JM, et al. Pharmacol Biochem Behav. 2017 Jun;157:35-40. doi: 10.1016/j.pbb.2017.04.009. Epub 2017 Apr 22. Pharmacol Biochem Behav. 2017. PMID: 28442369 Free PMC article.

6

Synthesis of (-)-11-O-Debenzoyltashironin: Neurotrophic Sesquiterpenes Cause Hyperexcitation.

Ohtawa M, Krambis MJ, Cerne R, Schkeryantz JM, Witkin JM, Shenvi RA. Ohtawa M, et al. Among authors: witkin jm. J Am Chem Soc. 2017 Jul 19;139(28):9637-9644. doi: 10.1021/jacs.7b04206. Epub 2017 Jul 6. J Am Chem Soc. 2017. PMID: 28644021

7

Targeted Blockade of TARP-γ8-Associated AMPA Receptors: Anticonvulsant Activity with the Selective Antagonist LY3130481 (CERC-611).

Witkin JM, Schober DA, Gleason SD, Catlow JT, Porter WJ, Reel J, Jin X, Hobbs J, Gehlert D, Gernert DL, Gardinier KM, Kato AS, Ping X, Smith JL. Witkin JM, et al. CNS Neurol Disord Drug Targets. 2017;16(10):1099-1110. doi: 10.2174/1871527316666171101132047. CNS Neurol Disord Drug Targets. 2017. PMID: 29090671

8

Protein complexes as psychiatric and neurological drug targets.

Kato AS, Witkin JM. Kato AS, et al. Among authors: witkin jm. Biochem Pharmacol. 2018 May;151:263-281. doi: 10.1016/j.bcp.2018.01.018. Epub 2018 Jan 9. Biochem Pharmacol. 2018. PMID: 29330067 Review.

9

Negative allosteric modulation of alpha 5-containing GABA_A receptors engenders antidepressant-like effects and selectively prevents age-associated hyperactivity in tau-depositing mice.

Xu NZ, Ernst M, Treven M, Cerne R, Wakulchik M, Li X, Jones TM, Gleason SD, Morrow D, Schkeryantz JM, Rahman MT, Li G, Poe MM, Cook JM, Witkin JM. Xu NZ, et al. Among authors: witkin jm. Psychopharmacology (Berl). 2018 Apr;235(4):1151-1161. doi: 10.1007/s00213-018-4832-9. Epub 2018 Jan 26. Psychopharmacology (Berl). 2018. PMID: 29374303

10

An antidepressant-related pharmacological signature for positive allosteric modulators of α2/3-containing GABA_A receptors.

Methuku KR, Li X, Cerne R, Gleason SD, Schkeryantz JM, Tiruveedhula VVNPB, Golani LK, Li G, Poe MM, Rahman MT, Cook JM, Fisher JL, Witkin JM. Methuku KR, et al. Among authors: witkin jm. Pharmacol Biochem Behav. 2018 Jul;170:9-13. doi: 10.1016/j.pbb.2018.04.009. Epub 2018 Apr 30. Pharmacol Biochem Behav. 2018. PMID: 29715490

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