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New ways to image and target tumour hypoxia and its molecular responses.
Dubois LJ, Niemans R, van Kuijk SJ, Panth KM, Parvathaneni NK, Peeters SG, Zegers CM, Rekers NH, van Gisbergen MW, Biemans R, Lieuwes NG, Spiegelberg L, Yaromina A, Winum JY, Vooijs M, Lambin P. Dubois LJ, et al. Among authors: winum jy. Radiother Oncol. 2015 Sep;116(3):352-7. doi: 10.1016/j.radonc.2015.08.022. Epub 2015 Aug 28. Radiother Oncol. 2015. PMID: 26324018 Free article. Review.
Targeting carbonic anhydrase IX by nitroimidazole based sulfamides enhances the therapeutic effect of tumor irradiation: a new concept of dual targeting drugs.
Dubois L, Peeters SG, van Kuijk SJ, Yaromina A, Lieuwes NG, Saraya R, Biemans R, Rami M, Parvathaneni NK, Vullo D, Vooijs M, Supuran CT, Winum JY, Lambin P. Dubois L, et al. Among authors: winum jy. Radiother Oncol. 2013 Sep;108(3):523-8. doi: 10.1016/j.radonc.2013.06.018. Epub 2013 Jul 9. Radiother Oncol. 2013. PMID: 23849171 Free article.
Evaluation of carbonic anhydrase IX as a therapeutic target for inhibition of breast cancer invasion and metastasis using a series of in vitro breast cancer models.
Ward C, Meehan J, Mullen P, Supuran C, Dixon JM, Thomas JS, Winum JY, Lambin P, Dubois L, Pavathaneni NK, Jarman EJ, Renshaw L, Um IH, Kay C, Harrison DJ, Kunkler IH, Langdon SP. Ward C, et al. Among authors: winum jy. Oncotarget. 2015 Sep 22;6(28):24856-70. doi: 10.18632/oncotarget.4498. Oncotarget. 2015. PMID: 26259239 Free PMC article.
Nitroimidazole-based inhibitors DTP338 and DTP348 are safe for zebrafish embryos and efficiently inhibit the activity of human CA IX in Xenopus oocytes.
Aspatwar A, Becker HM, Parvathaneni NK, Hammaren M, Svorjova A, Barker H, Supuran CT, Dubois L, Lambin P, Parikka M, Parkkila S, Winum JY. Aspatwar A, et al. Among authors: winum jy. J Enzyme Inhib Med Chem. 2018 Dec;33(1):1064-1073. doi: 10.1080/14756366.2018.1482285. J Enzyme Inhib Med Chem. 2018. PMID: 29909747 Free PMC article.
156 results