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Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function.
Hawe JS, Wilson R, Schmid KT, Zhou L, Lakshmanan LN, Lehne BC, Kühnel B, Scott WR, Wielscher M, Yew YW, Baumbach C, Lee DP, Marouli E, Bernard M, Pfeiffer L, Matías-García PR, Autio MI, Bourgeois S, Herder C, Karhunen V, Meitinger T, Prokisch H, Rathmann W, Roden M, Sebert S, Shin J, Strauch K, Zhang W, Tan WLW, Hauck SM, Merl-Pham J, Grallert H, Barbosa EGV; MuTHER Consortium; Illig T, Peters A, Paus T, Pausova Z, Deloukas P, Foo RSY, Jarvelin MR, Kooner JS, Loh M, Heinig M, Gieger C, Waldenberger M, Chambers JC. Hawe JS, et al. Among authors: wilson r. Nat Genet. 2022 Jan;54(1):18-29. doi: 10.1038/s41588-021-00969-x. Epub 2022 Jan 3. Nat Genet. 2022. PMID: 34980917
Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation.
Kato N, Loh M, Takeuchi F, Verweij N, Wang X, Zhang W, Kelly TN, Saleheen D, Lehne B, Leach IM, Drong AW, Abbott J, Wahl S, Tan ST, Scott WR, Campanella G, Chadeau-Hyam M, Afzal U, Ahluwalia TS, Bonder MJ, Chen P, Dehghan A, Edwards TL, Esko T, Go MJ, Harris SE, Hartiala J, Kasela S, Kasturiratne A, Khor CC, Kleber ME, Li H, Yu Mok Z, Nakatochi M, Sapari NS, Saxena R, Stewart AFR, Stolk L, Tabara Y, Teh AL, Wu Y, Wu JY, Zhang Y, Aits I, Da Silva Couto Alves A, Das S, Dorajoo R, Hopewell JC, Kim YK, Koivula RW, Luan J, Lyytikäinen LP, Nguyen QN, Pereira MA, Postmus I, Raitakari OT, Scannell Bryan M, Scott RA, Sorice R, Tragante V, Traglia M, White J, Yamamoto K, Zhang Y, Adair LS, Ahmed A, Akiyama K, Asif R, Aung T, Barroso I, Bjonnes A, Braun TR, Cai H, Chang LC, Chen CH, Cheng CY, Chong YS, Collins R, Courtney R, Davies G, Delgado G, Do LD, Doevendans PA, Gansevoort RT, Gao YT, Grammer TB, Grarup N, Grewal J, Gu D, Wander GS, Hartikainen AL, Hazen SL, He J, Heng CK, Hixson JE, Hofman A, Hsu C, Huang W, Husemoen LLN, Hwang JY, Ichihara S, Igase M, Isono M, Justesen JM, Katsuya T, Kibriya MG, Kim YJ, Kishimoto M, Koh WP, Kohara K, Kumari M, Kwek K, Lee NR, Lee J, Liao J, Lieb W, Li… See abstract for full author list ➔ Kato N, et al. Among authors: wilson r. Nat Genet. 2015 Nov;47(11):1282-1293. doi: 10.1038/ng.3405. Epub 2015 Sep 21. Nat Genet. 2015. PMID: 26390057 Free PMC article.
Ldlr-/- and ApoE-/- mice better mimic the human metabolite signature of increased carotid intima media thickness compared to other animal models of cardiovascular disease.
Saulnier-Blache JS, Wilson R, Klavins K, Graham D, Alesutan I, Kastenmüller G, Wang-Sattler R, Adamski J, Roden M, Rathmann W, Seissler J, Meisinger C, Koenig W, Thiery J, Suhre K, Peters A, Kuro-O M, Lang F, Dallmann G, Delles C, Voelkl J, Waldenberger M, Bascands JL, Klein J, Schanstra JP. Saulnier-Blache JS, et al. Among authors: wilson r. Atherosclerosis. 2018 Sep;276:140-147. doi: 10.1016/j.atherosclerosis.2018.07.024. Epub 2018 Jul 21. Atherosclerosis. 2018. PMID: 30059845
Association of maternal prenatal smoking GFI1-locus and cardio-metabolic phenotypes in 18,212 adults.
Parmar P, Lowry E, Cugliari G, Suderman M, Wilson R, Karhunen V, Andrew T, Wiklund P, Wielscher M, Guarrera S, Teumer A, Lehne B, Milani L, de Klein N, Mishra PP, Melton PE, Mandaviya PR, Kasela S, Nano J, Zhang W, Zhang Y, Uitterlinden AG, Peters A, Schöttker B, Gieger C, Anderson D, Boomsma DI, Grabe HJ, Panico S, Veldink JH, van Meurs JBJ, van den Berg L, Beilin LJ, Franke L, Loh M, van Greevenbroek MMJ, Nauck M, Kähönen M, Hurme MA, Raitakari OT, Franco OH, Slagboom PE, van der Harst P, Kunze S, Felix SB, Zhang T, Chen W, Mori TA, Bonnefond A, Heijmans BT; BIOS Consortium; Muka T, Kooner JS, Fischer K, Waldenberger M, Froguel P, Huang RC, Lehtimäki T, Rathmann W, Relton CL, Matullo G, Brenner H, Verweij N, Li S, Chambers JC, Järvelin MR, Sebert S; GLOBAL Meth QTL Consortium. Parmar P, et al. Among authors: wilson r. EBioMedicine. 2018 Dec;38:206-216. doi: 10.1016/j.ebiom.2018.10.066. Epub 2018 Nov 13. EBioMedicine. 2018. PMID: 30442561 Free PMC article.
Analysis of repeated leukocyte DNA methylation assessments reveals persistent epigenetic alterations after an incident myocardial infarction.
Ward-Caviness CK, Agha G, Chen BH, Pfeiffer L, Wilson R, Wolf P, Gieger C, Schwartz J, Vokonas PS, Hou L, Just AC, Bandinelli S, Hernandez DG, Singleton AB, Prokisch H, Meitinger T, Kastenmüller G, Ferrucci L, Baccarelli AA, Waldenberger M, Peters A. Ward-Caviness CK, et al. Among authors: wilson r. Clin Epigenetics. 2018 Dec 27;10(1):161. doi: 10.1186/s13148-018-0588-7. Clin Epigenetics. 2018. PMID: 30587240 Free PMC article.
Validated inference of smoking habits from blood with a finite DNA methylation marker set.
Maas SCE, Vidaki A, Wilson R, Teumer A, Liu F, van Meurs JBJ, Uitterlinden AG, Boomsma DI, de Geus EJC, Willemsen G, van Dongen J, van der Kallen CJH, Slagboom PE, Beekman M, van Heemst D, van den Berg LH; BIOS Consortium; Duijts L, Jaddoe VWV, Ladwig KH, Kunze S, Peters A, Ikram MA, Grabe HJ, Felix JF, Waldenberger M, Franco OH, Ghanbari M, Kayser M. Maas SCE, et al. Among authors: wilson r. Eur J Epidemiol. 2019 Nov;34(11):1055-1074. doi: 10.1007/s10654-019-00555-w. Epub 2019 Sep 7. Eur J Epidemiol. 2019. PMID: 31494793 Free PMC article.
Alcohol consumption is associated with widespread changes in blood DNA methylation: Analysis of cross-sectional and longitudinal data.
Dugué PA, Wilson R, Lehne B, Jayasekara H, Wang X, Jung CH, Joo JE, Makalic E, Schmidt DF, Baglietto L, Severi G, Gieger C, Ladwig KH, Peters A, Kooner JS, Southey MC, English DR, Waldenberger M, Chambers JC, Giles GG, Milne RL. Dugué PA, et al. Among authors: wilson r. Addict Biol. 2021 Jan;26(1):e12855. doi: 10.1111/adb.12855. Epub 2019 Dec 2. Addict Biol. 2021. PMID: 31789449
Epigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traits.
Zaghlool SB, Kühnel B, Elhadad MA, Kader S, Halama A, Thareja G, Engelke R, Sarwath H, Al-Dous EK, Mohamoud YA, Meitinger T, Wilson R, Strauch K, Peters A, Mook-Kanamori DO, Graumann J, Malek JA, Gieger C, Waldenberger M, Suhre K. Zaghlool SB, et al. Among authors: wilson r. Nat Commun. 2020 Jan 3;11(1):15. doi: 10.1038/s41467-019-13831-w. Nat Commun. 2020. PMID: 31900413 Free PMC article.
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