Williams S - Search Results

1

X-ray crystal structure of the liver X receptor beta ligand binding domain: regulation by a histidine-tryptophan switch.

Williams S, Bledsoe RK, Collins JL, Boggs S, Lambert MH, Miller AB, Moore J, McKee DD, Moore L, Nichols J, Parks D, Watson M, Wisely B, Willson TM. Williams S, et al. J Biol Chem. 2003 Jul 18;278(29):27138-43. doi: 10.1074/jbc.M302260200. Epub 2003 May 7. J Biol Chem. 2003. PMID: 12736258 Free article.

2

The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity.

Watkins RE, Wisely GB, Moore LB, Collins JL, Lambert MH, Williams SP, Willson TM, Kliewer SA, Redinbo MR. Watkins RE, et al. Among authors: williams sp. Science. 2001 Jun 22;292(5525):2329-33. doi: 10.1126/science.1060762. Epub 2001 Jun 14. Science. 2001. PMID: 11408620

3

Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids.

Wisely GB, Miller AB, Davis RG, Thornquest AD Jr, Johnson R, Spitzer T, Sefler A, Shearer B, Moore JT, Miller AB, Willson TM, Williams SP. Wisely GB, et al. Structure. 2002 Sep;10(9):1225-34. doi: 10.1016/s0969-2126(02)00829-8. Structure. 2002. PMID: 12220494 Free article.

4

A new series of estrogen receptor modulators that display selectivity for estrogen receptor beta.

Henke BR, Consler TG, Go N, Hale RL, Hohman DR, Jones SA, Lu AT, Moore LB, Moore JT, Orband-Miller LA, Robinett RG, Shearin J, Spearing PK, Stewart EL, Turnbull PS, Weaver SL, Williams SP, Wisely GB, Lambert MH. Henke BR, et al. Among authors: williams sp. J Med Chem. 2002 Dec 5;45(25):5492-505. doi: 10.1021/jm020291h. J Med Chem. 2002. PMID: 12459017

5

Helix 1/8 interactions influence the activity of nuclear receptor ligand-binding domains.

Holt JA, Consler TG, Williams SP, Ayscue AH, Leesnitzer LM, Wisely GB, Billin AN. Holt JA, et al. Mol Endocrinol. 2003 Sep;17(9):1704-14. doi: 10.1210/me.2003-0001. Epub 2003 Jun 19. Mol Endocrinol. 2003. PMID: 12817079

6

Progesterone receptor ligand binding pocket flexibility: crystal structures of the norethindrone and mometasone furoate complexes.

Madauss KP, Deng SJ, Austin RJ, Lambert MH, McLay I, Pritchard J, Short SA, Stewart EL, Uings IJ, Williams SP. Madauss KP, et al. J Med Chem. 2004 Jun 17;47(13):3381-7. doi: 10.1021/jm030640n. J Med Chem. 2004. PMID: 15189034

7

Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1.

Krylova IN, Sablin EP, Moore J, Xu RX, Waitt GM, MacKay JA, Juzumiene D, Bynum JM, Madauss K, Montana V, Lebedeva L, Suzawa M, Williams JD, Williams SP, Guy RK, Thornton JW, Fletterick RJ, Willson TM, Ingraham HA. Krylova IN, et al. Cell. 2005 Feb 11;120(3):343-55. doi: 10.1016/j.cell.2005.01.024. Cell. 2005. PMID: 15707893 Free article.

8

A ligand-mediated hydrogen bond network required for the activation of the mineralocorticoid receptor.

Bledsoe RK, Madauss KP, Holt JA, Apolito CJ, Lambert MH, Pearce KH, Stanley TB, Stewart EL, Trump RP, Willson TM, Williams SP. Bledsoe RK, et al. J Biol Chem. 2005 Sep 2;280(35):31283-93. doi: 10.1074/jbc.M504098200. Epub 2005 Jun 20. J Biol Chem. 2005. PMID: 15967794 Free article.

9

Crystallization of protein-ligand complexes.

Hassell AM, An G, Bledsoe RK, Bynum JM, Carter HL 3rd, Deng SJ, Gampe RT, Grisard TE, Madauss KP, Nolte RT, Rocque WJ, Wang L, Weaver KL, Williams SP, Wisely GB, Xu R, Shewchuk LM. Hassell AM, et al. Acta Crystallogr D Biol Crystallogr. 2007 Jan;63(Pt 1):72-9. doi: 10.1107/S0907444906047020. Epub 2006 Dec 13. Acta Crystallogr D Biol Crystallogr. 2007. PMID: 17164529 Free PMC article. Review.

10

Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064.

Akwabi-Ameyaw A, Bass JY, Caldwell RD, Caravella JA, Chen L, Creech KL, Deaton DN, Jones SA, Kaldor I, Liu Y, Madauss KP, Marr HB, McFadyen RB, Miller AB, Navas F III, Parks DJ, Spearing PK, Todd D, Williams SP, Wisely GB. Akwabi-Ameyaw A, et al. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4339-43. doi: 10.1016/j.bmcl.2008.06.073. Epub 2008 Jun 28. Bioorg Med Chem Lett. 2008. PMID: 18621523

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