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Page 1
Aster-dependent nonvesicular transport facilitates dietary cholesterol uptake.
Ferrari A, Whang E, Xiao X, Kennelly JP, Romartinez-Alonso B, Mack JJ, Weston T, Chen K, Kim Y, Tol MJ, Bideyan L, Nguyen A, Gao Y, Cui L, Bedard AH, Sandhu J, Lee SD, Fairall L, Williams KJ, Song W, Munguia P, Russell RA, Martin MG, Jung ME, Jiang H, Schwabe JWR, Young SG, Tontonoz P. Ferrari A, et al. Among authors: williams kj. Science. 2023 Nov 10;382(6671):eadf0966. doi: 10.1126/science.adf0966. Epub 2023 Nov 10. Science. 2023. PMID: 37943936 Free PMC article.
Interferon-mediated reprogramming of membrane cholesterol to evade bacterial toxins.
Zhou QD, Chi X, Lee MS, Hsieh WY, Mkrtchyan JJ, Feng AC, He C, York AG, Bui VL, Kronenberger EB, Ferrari A, Xiao X, Daly AE, Tarling EJ, Damoiseaux R, Scumpia PO, Smale ST, Williams KJ, Tontonoz P, Bensinger SJ. Zhou QD, et al. Among authors: williams kj. Nat Immunol. 2020 Jul;21(7):746-755. doi: 10.1038/s41590-020-0695-4. Epub 2020 Jun 8. Nat Immunol. 2020. PMID: 32514064 Free PMC article.
FXR activation protects against NAFLD via bile-acid-dependent reductions in lipid absorption.
Clifford BL, Sedgeman LR, Williams KJ, Morand P, Cheng A, Jarrett KE, Chan AP, Brearley-Sholto MC, Wahlström A, Ashby JW, Barshop W, Wohlschlegel J, Calkin AC, Liu Y, Thorell A, Meikle PJ, Drew BG, Mack JJ, Marschall HU, Tarling EJ, Edwards PA, de Aguiar Vallim TQ. Clifford BL, et al. Among authors: williams kj. Cell Metab. 2021 Aug 3;33(8):1671-1684.e4. doi: 10.1016/j.cmet.2021.06.012. Epub 2021 Jul 15. Cell Metab. 2021. PMID: 34270928 Free PMC article.
An essential requirement for the SCAP/SREBP signaling axis to protect cancer cells from lipotoxicity.
Williams KJ, Argus JP, Zhu Y, Wilks MQ, Marbois BN, York AG, Kidani Y, Pourzia AL, Akhavan D, Lisiero DN, Komisopoulou E, Henkin AH, Soto H, Chamberlain BT, Vergnes L, Jung ME, Torres JZ, Liau LM, Christofk HR, Prins RM, Mischel PS, Reue K, Graeber TG, Bensinger SJ. Williams KJ, et al. Cancer Res. 2013 May 1;73(9):2850-62. doi: 10.1158/0008-5472.CAN-13-0382-T. Epub 2013 Feb 25. Cancer Res. 2013. PMID: 23440422 Free PMC article.
Transgenic tomatoes expressing the 6F peptide and ezetimibe prevent diet-induced increases of IFN-β and cholesterol 25-hydroxylase in jejunum.
Mukherjee P, Hough G, Chattopadhyay A, Navab M, Fogelman HR, Meriwether D, Williams K, Bensinger S, Moller T, Faull KF, Lusis AJ, Iruela-Arispe ML, Bostrom KI, Tontonoz P, Reddy ST, Fogelman AM. Mukherjee P, et al. J Lipid Res. 2017 Aug;58(8):1636-1647. doi: 10.1194/jlr.M076554. Epub 2017 Jun 7. J Lipid Res. 2017. PMID: 28592401 Free PMC article.
Transintestinal transport of the anti-inflammatory drug 4F and the modulation of transintestinal cholesterol efflux.
Meriwether D, Sulaiman D, Wagner A, Grijalva V, Kaji I, Williams KJ, Yu L, Fogelman S, Volpe C, Bensinger SJ, Anantharamaiah GM, Shechter I, Fogelman AM, Reddy ST. Meriwether D, et al. Among authors: williams kj. J Lipid Res. 2016 Jul;57(7):1175-93. doi: 10.1194/jlr.M067025. Epub 2016 May 19. J Lipid Res. 2016. PMID: 27199144 Free PMC article.
Context-dependent regulation of ferroptosis sensitivity.
Magtanong L, Mueller GD, Williams KJ, Billmann M, Chan K, Armenta DA, Pope LE, Moffat J, Boone C, Myers CL, Olzmann JA, Bensinger SJ, Dixon SJ. Magtanong L, et al. Among authors: williams kj. Cell Chem Biol. 2022 Sep 15;29(9):1409-1418.e6. doi: 10.1016/j.chembiol.2022.06.004. Epub 2022 Jul 8. Cell Chem Biol. 2022. PMID: 35809566 Free PMC article.
Dynamic lipidome alterations associated with human health, disease and ageing.
Hornburg D, Wu S, Moqri M, Zhou X, Contrepois K, Bararpour N, Traber GM, Su B, Metwally AA, Avina M, Zhou W, Ubellacker JM, Mishra T, Schüssler-Fiorenza Rose SM, Kavathas PB, Williams KJ, Snyder MP. Hornburg D, et al. Among authors: williams kj. Nat Metab. 2023 Sep;5(9):1578-1594. doi: 10.1038/s42255-023-00880-1. Epub 2023 Sep 11. Nat Metab. 2023. PMID: 37697054 Free PMC article.
Targeting de novo lipid synthesis induces lipotoxicity and impairs DNA damage repair in glioblastoma mouse models.
Eyme KM, Sammarco A, Jha R, Mnatsakanyan H, Pechdimaljian C, Carvalho L, Neustadt R, Moses C, Alnasser A, Tardiff DF, Su B, Williams KJ, Bensinger SJ, Chung CY, Badr CE. Eyme KM, et al. Among authors: williams kj. Sci Transl Med. 2023 Jan 18;15(679):eabq6288. doi: 10.1126/scitranslmed.abq6288. Epub 2023 Jan 18. Sci Transl Med. 2023. PMID: 36652537 Free PMC article.
625 results