Williams AC - Search Results

1

NOTUM from Apc-mutant cells biases clonal competition to initiate cancer.

Flanagan DJ, Pentinmikko N, Luopajärvi K, Willis NJ, Gilroy K, Raven AP, Mcgarry L, Englund JI, Webb AT, Scharaw S, Nasreddin N, Hodder MC, Ridgway RA, Minnee E, Sphyris N, Gilchrist E, Najumudeen AK, Romagnolo B, Perret C, Williams AC, Clevers H, Nummela P, Lähde M, Alitalo K, Hietakangas V, Hedley A, Clark W, Nixon C, Kirschner K, Jones EY, Ristimäki A, Leedham SJ, Fish PV, Vincent JP, Katajisto P, Sansom OJ. Flanagan DJ, et al. Among authors: williams ac. Nature. 2021 Jun;594(7863):430-435. doi: 10.1038/s41586-021-03525-z. Epub 2021 Jun 2. Nature. 2021. PMID: 34079124 Free PMC article.

2

Cancer cell adaptation to hypoxia involves a HIF-GPRC5A-YAP axis.

Greenhough A, Bagley C, Heesom KJ, Gurevich DB, Gay D, Bond M, Collard TJ, Paraskeva C, Martin P, Sansom OJ, Malik K, Williams AC. Greenhough A, et al. Among authors: williams ac. EMBO Mol Med. 2018 Nov;10(11):e8699. doi: 10.15252/emmm.201708699. EMBO Mol Med. 2018. PMID: 30143543 Free PMC article.

3

BCL-3 loss sensitises colorectal cancer cells to DNA damage by targeting homologous recombination.

Parker C, Chambers AC, Flanagan DJ, Ho JWY, Collard TJ, Ngo G, Baird DM, Timms P, Morgan RG, Sansom OJ, Williams AC. Parker C, et al. Among authors: williams ac. DNA Repair (Amst). 2022 Jul;115:103331. doi: 10.1016/j.dnarep.2022.103331. Epub 2022 Apr 16. DNA Repair (Amst). 2022. PMID: 35468497 Free PMC article.

4

Aspirin reprogrammes colorectal cancer cell metabolism and sensitises to glutaminase inhibition.

Holt AK, Najumudeen AK, Collard TJ, Li H, Millett LM, Hoskin AJ, Legge DN, Mortensson EMH, Flanagan DJ, Jones N, Kollareddy M, Timms P, Hitchings MD, Cronin J, Sansom OJ, Williams AC, Vincent EE. Holt AK, et al. Among authors: williams ac. Cancer Metab. 2023 Oct 19;11(1):18. doi: 10.1186/s40170-023-00318-y. Cancer Metab. 2023. PMID: 37858256 Free PMC article.

5

Differential sensitivity of human colonic adenoma and carcinoma cells to transforming growth factor beta (TGF-beta): conversion of an adenoma cell line to a tumorigenic phenotype is accompanied by a reduced response to the inhibitory effects of TGF-beta.

Manning AM, Williams AC, Game SM, Paraskeva C. Manning AM, et al. Among authors: williams ac. Oncogene. 1991 Aug;6(8):1471-6. Oncogene. 1991. PMID: 1886718

6

Colorectal carcinogenesis: sequential steps in the in vitro immortalization and transformation of human colonic epithelial cells (review).

Paraskeva C, Corfield AP, Harper S, Hague A, Audcent K, Williams AC. Paraskeva C, et al. Among authors: williams ac. Anticancer Res. 1990 Sep-Oct;10(5A):1189-200. Anticancer Res. 1990. PMID: 2241098 Review.

7

Mutant p53 is not fully dominant over endogenous wild type p53 in a colorectal adenoma cell line as demonstrated by induction of MDM2 protein and retention of a p53 dependent G1 arrest after gamma irradiation.

Williams AC, Miller JC, Collard TJ, Bracey TS, Cosulich S, Paraskeva C. Williams AC, et al. Oncogene. 1995 Jul 6;11(1):141-9. Oncogene. 1995. PMID: 7624121

8

Loss of APC protein expressed by human colonic epithelial cells and the appearance of a specific low-molecular-weight form is associated with apoptosis in vitro.

Browne SJ, Williams AC, Hague A, Butt AJ, Paraskeva C. Browne SJ, et al. Among authors: williams ac. Int J Cancer. 1994 Oct 1;59(1):56-64. doi: 10.1002/ijc.2910590113. Int J Cancer. 1994. PMID: 7927905

9

Transfection and expression of mutant p53 protein does not alter the in vivo or in vitro growth characteristics of the AA/C1 human adenoma derived cell line, including sensitivity to transforming growth factor-beta 1.

Williams AC, Browne SJ, Manning AM, Daffada P, Collard TJ, Paraskeva C. Williams AC, et al. Oncogene. 1994 May;9(5):1479-85. Oncogene. 1994. PMID: 8152811

10

Biological consequences of the genetic changes which occur during human colorectal carcinogenesis.

Williams AC, Browne SJ, Manning AM, Hague A, van der Stappen JW, Paraskeva C. Williams AC, et al. Semin Cancer Biol. 1993 Jun;4(3):153-9. Semin Cancer Biol. 1993. PMID: 8318691 Review.

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