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APRIL limits atherosclerosis by binding to heparan sulfate proteoglycans.
Tsiantoulas D, Eslami M, Obermayer G, Clement M, Smeets D, Mayer FJ, Kiss MG, Enders L, Weißer J, Göderle L, Lambert J, Frommlet F, Mueller A, Hendrikx T, Ozsvar-Kozma M, Porsch F, Willen L, Afonyushkin T, Murphy JE, Fogelstrand P, Donzé O, Pasterkamp G, Hoke M, Kubicek S, Jørgensen HF, Danchin N, Simon T, Scharnagl H, März W, Borén J, Hess H, Mallat Z, Schneider P, Binder CJ. Tsiantoulas D, et al. Among authors: willen l. Nature. 2021 Sep;597(7874):92-96. doi: 10.1038/s41586-021-03818-3. Epub 2021 Aug 25. Nature. 2021. PMID: 34433968
TACI, unlike BAFF-R, is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablasts.
Bossen C, Cachero TG, Tardivel A, Ingold K, Willen L, Dobles M, Scott ML, Maquelin A, Belnoue E, Siegrist CA, Chevrier S, Acha-Orbea H, Leung H, Mackay F, Tschopp J, Schneider P. Bossen C, et al. Among authors: willen l. Blood. 2008 Feb 1;111(3):1004-12. doi: 10.1182/blood-2007-09-110874. Epub 2007 Oct 17. Blood. 2008. PMID: 17942754 Free article.
Generation and characterization of function-blocking anti-ectodysplasin A (EDA) monoclonal antibodies that induce ectodermal dysplasia.
Kowalczyk-Quintas C, Willen L, Dang AT, Sarrasin H, Tardivel A, Hermes K, Schneider H, Gaide O, Donzé O, Kirby N, Headon DJ, Schneider P. Kowalczyk-Quintas C, et al. Among authors: willen l. J Biol Chem. 2014 Feb 14;289(7):4273-85. doi: 10.1074/jbc.M113.535740. Epub 2014 Jan 3. J Biol Chem. 2014. PMID: 24391090 Free PMC article.
Stoichiometry of Heteromeric BAFF and APRIL Cytokines Dictates Their Receptor Binding and Signaling Properties.
Schuepbach-Mallepell S, Das D, Willen L, Vigolo M, Tardivel A, Lebon L, Kowalczyk-Quintas C, Nys J, Smulski C, Zheng TS, Maskos K, Lammens A, Jiang X, Hess H, Tan SL, Schneider P. Schuepbach-Mallepell S, et al. Among authors: willen l. J Biol Chem. 2015 Jun 26;290(26):16330-42. doi: 10.1074/jbc.M115.661405. Epub 2015 May 7. J Biol Chem. 2015. PMID: 25953898 Free PMC article.
Antibodies That Block or Activate Mouse B Cell Activating Factor of the Tumor Necrosis Factor (TNF) Family (BAFF), Respectively, Induce B Cell Depletion or B Cell Hyperplasia.
Kowalczyk-Quintas C, Schuepbach-Mallepell S, Vigolo M, Willen L, Tardivel A, Smulski CR, Zheng TS, Gommerman J, Hess H, Gottenberg JE, Mackay F, Donzé O, Schneider P. Kowalczyk-Quintas C, et al. Among authors: willen l. J Biol Chem. 2016 Sep 16;291(38):19826-34. doi: 10.1074/jbc.M116.725929. Epub 2016 Jul 22. J Biol Chem. 2016. PMID: 27451394 Free PMC article.
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