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Activation of bile salt nuclear receptor FXR is repressed by pro-inflammatory cytokines activating NF-κB signaling in the intestine.
Gadaleta RM, Oldenburg B, Willemsen EC, Spit M, Murzilli S, Salvatore L, Klomp LW, Siersema PD, van Erpecum KJ, van Mil SW. Gadaleta RM, et al. Among authors: willemsen ec. Biochim Biophys Acta. 2011 Aug;1812(8):851-8. doi: 10.1016/j.bbadis.2011.04.005. Epub 2011 Apr 22. Biochim Biophys Acta. 2011. PMID: 21540105 Free article.
Farnesoid X Receptor Activation Promotes Hepatic Amino Acid Catabolism and Ammonium Clearance in Mice.
Massafra V, Milona A, Vos HR, Ramos RJJ, Gerrits J, Willemsen ECL, Ramos Pittol JM, Ijssennagger N, Houweling M, Prinsen HCMT, Verhoeven-Duif NM, Burgering BMT, van Mil SWC. Massafra V, et al. Among authors: willemsen ecl. Gastroenterology. 2017 May;152(6):1462-1476.e10. doi: 10.1053/j.gastro.2017.01.014. Epub 2017 Jan 25. Gastroenterology. 2017. PMID: 28130067 Free article.
Characterization of stem cell-derived liver and intestinal organoids as a model system to study nuclear receptor biology.
Bijsmans IT, Milona A, Ijssennagger N, Willemsen EC, Ramos Pittol JM, Jonker JW, Lange K, Hooiveld GJ, van Mil SW. Bijsmans IT, et al. Among authors: willemsen ec. Biochim Biophys Acta Mol Basis Dis. 2017 Mar;1863(3):687-700. doi: 10.1016/j.bbadis.2016.12.004. Epub 2016 Dec 10. Biochim Biophys Acta Mol Basis Dis. 2017. PMID: 27956139 Free article.
Steroidogenic control of liver metabolism through a nuclear receptor-network.
Milona A, Massafra V, Vos H, Naik J, Artigas N, Paterson HAB, Bijsmans ITGW, Willemsen ECL, Ramos Pittol JM, Miguel-Aliaga I, Bosma P, Burgering BMT, Williamson C, Vernia S, Dhillo WS, van Mil SWC, Owen BM. Milona A, et al. Among authors: willemsen ecl. Mol Metab. 2019 Dec;30:221-229. doi: 10.1016/j.molmet.2019.09.007. Epub 2019 Sep 30. Mol Metab. 2019. PMID: 31767173 Free PMC article.
Ablation of liver Fxr results in an increased colonic mucus barrier in mice.
Ijssennagger N, van Rooijen KS, Magnúsdóttir S, Ramos Pittol JM, Willemsen ECL, de Zoete MR, Baars MJD, Stege PB, Colliva C, Pellicciari R, Youssef SA, de Bruin A, Vercoulen Y, Kuipers F, van Mil SWC. Ijssennagger N, et al. Among authors: willemsen ecl. JHEP Rep. 2021 Aug 4;3(5):100344. doi: 10.1016/j.jhepr.2021.100344. eCollection 2021 Oct. JHEP Rep. 2021. PMID: 34604725 Free PMC article.