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Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease.
Gut. 2011 Apr;60(4):463-72. doi: 10.1136/gut.2010.212159. Epub 2011 Jan 17.
Gut. 2011.
PMID: 21242261
Activation of bile salt nuclear receptor FXR is repressed by pro-inflammatory cytokines activating NF-κB signaling in the intestine.
Gadaleta RM, Oldenburg B, Willemsen EC, Spit M, Murzilli S, Salvatore L, Klomp LW, Siersema PD, van Erpecum KJ, van Mil SW.
Gadaleta RM, et al. Among authors: willemsen ec.
Biochim Biophys Acta. 2011 Aug;1812(8):851-8. doi: 10.1016/j.bbadis.2011.04.005. Epub 2011 Apr 22.
Biochim Biophys Acta. 2011.
PMID: 21540105
Free article.
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Farnesoid X Receptor Activation Promotes Hepatic Amino Acid Catabolism and Ammonium Clearance in Mice.
Massafra V, Milona A, Vos HR, Ramos RJJ, Gerrits J, Willemsen ECL, Ramos Pittol JM, Ijssennagger N, Houweling M, Prinsen HCMT, Verhoeven-Duif NM, Burgering BMT, van Mil SWC.
Massafra V, et al. Among authors: willemsen ecl.
Gastroenterology. 2017 May;152(6):1462-1476.e10. doi: 10.1053/j.gastro.2017.01.014. Epub 2017 Jan 25.
Gastroenterology. 2017.
PMID: 28130067
Free article.
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Characterization of stem cell-derived liver and intestinal organoids as a model system to study nuclear receptor biology.
Bijsmans IT, Milona A, Ijssennagger N, Willemsen EC, Ramos Pittol JM, Jonker JW, Lange K, Hooiveld GJ, van Mil SW.
Bijsmans IT, et al. Among authors: willemsen ec.
Biochim Biophys Acta Mol Basis Dis. 2017 Mar;1863(3):687-700. doi: 10.1016/j.bbadis.2016.12.004. Epub 2016 Dec 10.
Biochim Biophys Acta Mol Basis Dis. 2017.
PMID: 27956139
Free article.
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FXR Isoforms Control Different Metabolic Functions in Liver Cells via Binding to Specific DNA Motifs.
Ramos Pittol JM, Milona A, Morris I, Willemsen ECL, van der Veen SW, Kalkhoven E, van Mil SWC.
Ramos Pittol JM, et al. Among authors: willemsen ecl.
Gastroenterology. 2020 Nov;159(5):1853-1865.e10. doi: 10.1053/j.gastro.2020.07.036. Epub 2020 Jul 23.
Gastroenterology. 2020.
PMID: 32712104
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Raised hepatic bile acid concentrations during pregnancy in mice are associated with reduced farnesoid X receptor function.
Milona A, Owen BM, Cobbold JF, Willemsen EC, Cox IJ, Boudjelal M, Cairns W, Schoonjans K, Taylor-Robinson SD, Klomp LW, Parker MG, White R, van Mil SW, Williamson C.
Milona A, et al. Among authors: willemsen ec.
Hepatology. 2010 Oct;52(4):1341-9. doi: 10.1002/hep.23849.
Hepatology. 2010.
PMID: 20842631
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Steroidogenic control of liver metabolism through a nuclear receptor-network.
Milona A, Massafra V, Vos H, Naik J, Artigas N, Paterson HAB, Bijsmans ITGW, Willemsen ECL, Ramos Pittol JM, Miguel-Aliaga I, Bosma P, Burgering BMT, Williamson C, Vernia S, Dhillo WS, van Mil SWC, Owen BM.
Milona A, et al. Among authors: willemsen ecl.
Mol Metab. 2019 Dec;30:221-229. doi: 10.1016/j.molmet.2019.09.007. Epub 2019 Sep 30.
Mol Metab. 2019.
PMID: 31767173
Free PMC article.
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Ablation of liver Fxr results in an increased colonic mucus barrier in mice.
Ijssennagger N, van Rooijen KS, Magnúsdóttir S, Ramos Pittol JM, Willemsen ECL, de Zoete MR, Baars MJD, Stege PB, Colliva C, Pellicciari R, Youssef SA, de Bruin A, Vercoulen Y, Kuipers F, van Mil SWC.
Ijssennagger N, et al. Among authors: willemsen ecl.
JHEP Rep. 2021 Aug 4;3(5):100344. doi: 10.1016/j.jhepr.2021.100344. eCollection 2021 Oct.
JHEP Rep. 2021.
PMID: 34604725
Free PMC article.
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