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The pseudo signal peptide of the corticotropin-releasing factor receptor type 2a decreases receptor expression and prevents Gi-mediated inhibition of adenylyl cyclase activity.
Schulz K, Rutz C, Westendorf C, Ridelis I, Vogelbein S, Furkert J, Schmidt A, Wiesner B, Schülein R. Schulz K, et al. Among authors: wiesner b. J Biol Chem. 2010 Oct 22;285(43):32878-32887. doi: 10.1074/jbc.M110.129627. Epub 2010 Aug 3. J Biol Chem. 2010. PMID: 20682782 Free PMC article.
New pathogenic thyrotropin receptor mutations decipher differentiated activity switching at a conserved helix 6 motif of family A GPCR.
Biebermann H, Winkler F, Handke D, Teichmann A, Gerling B, Cameron F, Eichhorst J, Grüters A, Wiesner B, Kühnen P, Krude H, Kleinau G. Biebermann H, et al. Among authors: wiesner b. J Clin Endocrinol Metab. 2012 Feb;97(2):E228-32. doi: 10.1210/jc.2011-2106. Epub 2011 Nov 23. J Clin Endocrinol Metab. 2012. PMID: 22112806
240 results