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Multiple endpoint in vitro toxicity assessment of a prototype heated tobacco product indicates substantially reduced effects compared to those of combustible cigarette.
Chapman F, Sticken ET, Wieczorek R, Pour SJ, Dethloff O, Budde J, Rudd K, Mason E, Czekala L, Yu F, Simms L, Nahde T, O'Connell G, Stevenson M. Chapman F, et al. Among authors: wieczorek r. Toxicol In Vitro. 2023 Feb;86:105510. doi: 10.1016/j.tiv.2022.105510. Epub 2022 Nov 11. Toxicol In Vitro. 2023. PMID: 36372310 Free article.
The in vitro ToxTracker and Aneugen Clastogen Evaluation extension assay as a tool in the assessment of relative genotoxic potential of e-liquids and their aerosols.
Czekala L, Chapman F, Simms L, Rudd K, Trelles Sticken E, Wieczorek R, Bode LM, Pani J, Moelijker N, Derr R, Brandsma I, Hendriks G, Stevenson M, Walele T. Czekala L, et al. Among authors: wieczorek r. Mutagenesis. 2021 May 31;36(2):129-142. doi: 10.1093/mutage/geaa033. Mutagenesis. 2021. PMID: 33769537 Free PMC article.
The use of human induced pluripotent stem cells to screen for developmental toxicity potential indicates reduced potential for non-combusted products, when compared to cigarettes.
Simms L, Rudd K, Palmer J, Czekala L, Yu F, Chapman F, Trelles Sticken E, Wieczorek R, Bode LM, Stevenson M, Walele T. Simms L, et al. Among authors: wieczorek r. Curr Res Toxicol. 2020 Nov 15;1:161-173. doi: 10.1016/j.crtox.2020.11.001. eCollection 2020 Jun 10. Curr Res Toxicol. 2020. PMID: 34345845 Free PMC article.
Multi-endpoint analysis of human 3D airway epithelium following repeated exposure to whole electronic vapor product aerosol or cigarette smoke.
Czekala L, Wieczorek R, Simms L, Yu F, Budde J, Trelles Sticken E, Rudd K, Verron T, Brinster O, Stevenson M, Walele T. Czekala L, et al. Among authors: wieczorek r. Curr Res Toxicol. 2021 Feb 20;2:99-115. doi: 10.1016/j.crtox.2021.02.004. eCollection 2021. Curr Res Toxicol. 2021. PMID: 34345855 Free PMC article.
Key challenges for in vitro testing of tobacco products for regulatory applications: Recommendations for dosimetry.
Miller-Holt J, Behrsing H, Crooks I, Curren R, Demir K, Gafner J, Gillman G, Hollings M, Leverette R, Oldham M, Simms L, Stankowski LF Jr, Thorne D, Wieczorek R, Moore MM. Miller-Holt J, et al. Among authors: wieczorek r. Drug Test Anal. 2023 Oct;15(10):1175-1188. doi: 10.1002/dta.3344. Epub 2022 Aug 16. Drug Test Anal. 2023. PMID: 35830202 Free PMC article.
Ciliary Beat Frequency: Proceedings and Recommendations from a Multi-laboratory Ring Trial Using 3-D Reconstituted Human Airway Epithelium to Model Mucociliary Clearance.
Behrsing HP, Wahab A, Ukishima L, Grodi C, Frentzel S, Johne S, Ishikawa S, Ito S, Wieczorek R, Budde J, Keyser BM, Haswell LE, Thorne D, Bishop E, Breheny D, Cao X, Qin Q, Patel V. Behrsing HP, et al. Among authors: wieczorek r. Altern Lab Anim. 2022 Jul;50(4):293-309. doi: 10.1177/02611929221114383. Epub 2022 Aug 7. Altern Lab Anim. 2022. PMID: 35938181
175 results