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BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design.
Farnaby W, Koegl M, Roy MJ, Whitworth C, Diers E, Trainor N, Zollman D, Steurer S, Karolyi-Oezguer J, Riedmueller C, Gmaschitz T, Wachter J, Dank C, Galant M, Sharps B, Rumpel K, Traxler E, Gerstberger T, Schnitzer R, Petermann O, Greb P, Weinstabl H, Bader G, Zoephel A, Weiss-Puxbaum A, Ehrenhöfer-Wölfer K, Wöhrle S, Boehmelt G, Rinnenthal J, Arnhof H, Wiechens N, Wu MY, Owen-Hughes T, Ettmayer P, Pearson M, McConnell DB, Ciulli A. Farnaby W, et al. Among authors: wiechens n. Nat Chem Biol. 2019 Jul;15(7):672-680. doi: 10.1038/s41589-019-0294-6. Epub 2019 Jun 10. Nat Chem Biol. 2019. PMID: 31178587 Free PMC article.
Sin mutations alter inherent nucleosome mobility.
Flaus A, Rencurel C, Ferreira H, Wiechens N, Owen-Hughes T. Flaus A, et al. Among authors: wiechens n. EMBO J. 2004 Jan 28;23(2):343-53. doi: 10.1038/sj.emboj.7600047. Epub 2004 Jan 15. EMBO J. 2004. PMID: 14726954 Free PMC article.
Nucleosome dynamics.
Stockdale C, Bruno M, Ferreira H, Garcia-Wilson E, Wiechens N, Engeholm M, Flaus A, Owen-Hughes T. Stockdale C, et al. Among authors: wiechens n. Biochem Soc Symp. 2006;(73):109-19. doi: 10.1042/bss0730109. Biochem Soc Symp. 2006. PMID: 16626292 Review.
The PHD and chromo domains regulate the ATPase activity of the human chromatin remodeler CHD4.
Watson AA, Mahajan P, Mertens HD, Deery MJ, Zhang W, Pham P, Du X, Bartke T, Zhang W, Edlich C, Berridge G, Chen Y, Burgess-Brown NA, Kouzarides T, Wiechens N, Owen-Hughes T, Svergun DI, Gileadi O, Laue ED. Watson AA, et al. Among authors: wiechens n. J Mol Biol. 2012 Sep 7;422(1):3-17. doi: 10.1016/j.jmb.2012.04.031. Epub 2012 May 7. J Mol Biol. 2012. PMID: 22575888 Free PMC article.
Publisher Correction: BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design.
Farnaby W, Koegl M, Roy MJ, Whitworth C, Diers E, Trainor N, Zollman D, Steurer S, Karolyi-Oezguer J, Riedmueller C, Gmaschitz T, Wachter J, Dank C, Galant M, Sharps B, Rumpel K, Traxler E, Gerstberger T, Schnitzer R, Petermann O, Greb P, Weinstabl H, Bader G, Zoephel A, Weiss-Puxbaum A, Ehrenhöfer-Wölfer K, Wöhrle S, Boehmelt G, Rinnenthal J, Arnhof H, Wiechens N, Wu MY, Owen-Hughes T, Ettmayer P, Pearson M, McConnell DB, Ciulli A. Farnaby W, et al. Among authors: wiechens n. Nat Chem Biol. 2019 Aug;15(8):846. doi: 10.1038/s41589-019-0329-z. Nat Chem Biol. 2019. PMID: 31267096
Acute depletion of the ARID1A subunit of SWI/SNF complexes reveals distinct pathways for activation and repression of transcription.
Blümli S, Wiechens N, Wu MY, Singh V, Gierlinski M, Schweikert G, Gilbert N, Naughton C, Sundaramoorthy R, Varghese J, Gourlay R, Soares R, Clark D, Owen-Hughes T. Blümli S, et al. Among authors: wiechens n. Cell Rep. 2021 Nov 2;37(5):109943. doi: 10.1016/j.celrep.2021.109943. Cell Rep. 2021. PMID: 34731603 Free PMC article.
18 results