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The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.
Krastev DB, Li S, Sun Y, Wicks AJ, Hoslett G, Weekes D, Badder LM, Knight EG, Marlow R, Pardo MC, Yu L, Talele TT, Bartek J, Choudhary JS, Pommier Y, Pettitt SJ, Tutt ANJ, Ramadan K, Lord CJ. Krastev DB, et al. Among authors: wicks aj. Nat Cell Biol. 2022 Jan;24(1):62-73. doi: 10.1038/s41556-021-00807-6. Epub 2022 Jan 10. Nat Cell Biol. 2022. PMID: 35013556 Free PMC article.
Sirtuin inhibition is synthetic lethal with BRCA1 or BRCA2 deficiency.
Bajrami I, Walker C, Krastev DB, Weekes D, Song F, Wicks AJ, Alexander J, Haider S, Brough R, Pettitt SJ, Tutt ANJ, Lord CJ. Bajrami I, et al. Among authors: wicks aj. Commun Biol. 2021 Nov 8;4(1):1270. doi: 10.1038/s42003-021-02770-2. Commun Biol. 2021. PMID: 34750509 Free PMC article.
PARP Inhibitors - Trapped in a Toxic Love Affair.
Krastev DB, Wicks AJ, Lord CJ. Krastev DB, et al. Among authors: wicks aj. Cancer Res. 2021 Nov 15;81(22):5605-5607. doi: 10.1158/0008-5472.CAN-21-3201. Cancer Res. 2021. PMID: 34782321
Structural basis for allosteric PARP-1 retention on DNA breaks.
Zandarashvili L, Langelier MF, Velagapudi UK, Hancock MA, Steffen JD, Billur R, Hannan ZM, Wicks AJ, Krastev DB, Pettitt SJ, Lord CJ, Talele TT, Pascal JM, Black BE. Zandarashvili L, et al. Among authors: wicks aj. Science. 2020 Apr 3;368(6486):eaax6367. doi: 10.1126/science.aax6367. Science. 2020. PMID: 32241924 Free PMC article.
A field study of the generation of nitrate in a hill cap cloud.
Choularton TW, Wicks AJ, Downer RM, Gallagher MW, Penkett SA, Bandy BJ, Dollard GJ, Jones BM, Davies TD, Gay MJ, Tyler BJ, Fowler D, Cape JN, Hargreaves KJ. Choularton TW, et al. Among authors: wicks aj. Environ Pollut. 1992;75(1):69-73. doi: 10.1016/0269-7491(92)90058-i. Environ Pollut. 1992. PMID: 15092051