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Adhesion between P. falciparum infected erythrocytes and human endothelial receptors follows alternative binding dynamics under flow and febrile conditions.
Lubiana P, Bouws P, Roth LK, Dörpinghaus M, Rehn T, Brehmer J, Wichers JS, Bachmann A, Höhn K, Roeder T, Thye T, Gutsmann T, Burmester T, Bruchhaus I, Metwally NG. Lubiana P, et al. Among authors: wichers js. Sci Rep. 2020 Mar 11;10(1):4548. doi: 10.1038/s41598-020-61388-2. Sci Rep. 2020. PMID: 32161335 Free PMC article.
Common virulence gene expression in adult first-time infected malaria patients and severe cases.
Wichers JS, Tonkin-Hill G, Thye T, Krumkamp R, Kreuels B, Strauss J, von Thien H, Scholz JA, Smedegaard Hansson H, Weisel Jensen R, Turner L, Lorenz FR, Schöllhorn A, Bruchhaus I, Tannich E, Fendel R, Otto TD, Lavstsen T, Gilberger TW, Duffy MF, Bachmann A. Wichers JS, et al. Elife. 2021 Apr 28;10:e69040. doi: 10.7554/eLife.69040. Elife. 2021. PMID: 33908865 Free PMC article.
Controlled human malaria infection with Plasmodium falciparum demonstrates impact of naturally acquired immunity on virulence gene expression.
Bachmann A, Bruske E, Krumkamp R, Turner L, Wichers JS, Petter M, Held J, Duffy MF, Sim BKL, Hoffman SL, Kremsner PG, Lell B, Lavstsen T, Frank M, Mordmüller B, Tannich E. Bachmann A, et al. Among authors: wichers js. PLoS Pathog. 2019 Jul 11;15(7):e1007906. doi: 10.1371/journal.ppat.1007906. eCollection 2019 Jul. PLoS Pathog. 2019. PMID: 31295334 Free PMC article. Clinical Trial.
PMRT1, a Plasmodium-Specific Parasite Plasma Membrane Transporter, Is Essential for Asexual and Sexual Blood Stage Development.
Wichers JS, Mesén-Ramírez P, Fuchs G, Yu-Strzelczyk J, Stäcker J, von Thien H, Alder A, Henshall I, Liffner B, Nagel G, Löw C, Wilson D, Spielmann T, Gao S, Gilberger TW, Bachmann A, Strauss J. Wichers JS, et al. mBio. 2022 Apr 26;13(2):e0062322. doi: 10.1128/mbio.00623-22. Epub 2022 Apr 11. mBio. 2022. PMID: 35404116 Free PMC article.
Structural Insights Into PfARO and Characterization of its Interaction With PfAIP.
Geiger M, Brown C, Wichers JS, Strauss J, Lill A, Thuenauer R, Liffner B, Wilcke L, Lemcke S, Heincke D, Pazicky S, Bachmann A, Löw C, Wilson DW, Filarsky M, Burda PC, Zhang K, Junop M, Gilberger TW. Geiger M, et al. Among authors: wichers js. J Mol Biol. 2020 Feb 14;432(4):878-896. doi: 10.1016/j.jmb.2019.12.024. Epub 2019 Dec 23. J Mol Biol. 2020. PMID: 31877322
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