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A randomized, placebo-controlled phase 2 study of paclitaxel in combination with reparixin compared to paclitaxel alone as front-line therapy for metastatic triple-negative breast cancer (fRida).
Goldstein LJ, Mansutti M, Levy C, Chang JC, Henry S, Fernandez-Perez I, Prausovà J, Staroslawska E, Viale G, Butler B, McCanna S, Ruffini PA, Wicha MS, Schott AF; fRida Trial Investigators. Goldstein LJ, et al. Among authors: wicha ms. Breast Cancer Res Treat. 2021 Nov;190(2):265-275. doi: 10.1007/s10549-021-06367-5. Epub 2021 Sep 3. Breast Cancer Res Treat. 2021. PMID: 34476645 Free PMC article. Clinical Trial.
Preclinical and clinical studies of gamma secretase inhibitors with docetaxel on human breast tumors.
Schott AF, Landis MD, Dontu G, Griffith KA, Layman RM, Krop I, Paskett LA, Wong H, Dobrolecki LE, Lewis MT, Froehlich AM, Paranilam J, Hayes DF, Wicha MS, Chang JC. Schott AF, et al. Among authors: wicha ms. Clin Cancer Res. 2013 Mar 15;19(6):1512-24. doi: 10.1158/1078-0432.CCR-11-3326. Epub 2013 Jan 22. Clin Cancer Res. 2013. PMID: 23340294 Free PMC article. Clinical Trial.
HER2 drives luminal breast cancer stem cells in the absence of HER2 amplification: implications for efficacy of adjuvant trastuzumab.
Ithimakin S, Day KC, Malik F, Zen Q, Dawsey SJ, Bersano-Begey TF, Quraishi AA, Ignatoski KW, Daignault S, Davis A, Hall CL, Palanisamy N, Heath AN, Tawakkol N, Luther TK, Clouthier SG, Chadwick WA, Day ML, Kleer CG, Thomas DG, Hayes DF, Korkaya H, Wicha MS. Ithimakin S, et al. Among authors: wicha ms. Cancer Res. 2013 Mar 1;73(5):1635-46. doi: 10.1158/0008-5472.CAN-12-3349. Epub 2013 Feb 26. Cancer Res. 2013. PMID: 23442322 Free PMC article.
HER2 and breast cancer stem cells: more than meets the eye.
Korkaya H, Wicha MS. Korkaya H, et al. Among authors: wicha ms. Cancer Res. 2013 Jun 15;73(12):3489-93. doi: 10.1158/0008-5472.CAN-13-0260. Epub 2013 Jun 5. Cancer Res. 2013. PMID: 23740771 Free PMC article. Review.
CRLX101, an investigational camptothecin-containing nanoparticle-drug conjugate, targets cancer stem cells and impedes resistance to antiangiogenic therapy in mouse models of breast cancer.
Conley SJ, Baker TL, Burnett JP, Theisen RL, Lazarus D, Peters CG, Clouthier SG, Eliasof S, Wicha MS. Conley SJ, et al. Among authors: wicha ms. Breast Cancer Res Treat. 2015 Apr;150(3):559-67. doi: 10.1007/s10549-015-3349-8. Epub 2015 Apr 2. Breast Cancer Res Treat. 2015. PMID: 25833208
Clinical predictors of long-term survival in HER2-positive metastatic breast cancer.
Murthy P, Kidwell KM, Schott AF, Merajver SD, Griggs JJ, Smerage JD, Van Poznak CH, Wicha MS, Hayes DF, Henry NL. Murthy P, et al. Among authors: wicha ms. Breast Cancer Res Treat. 2016 Feb;155(3):589-95. doi: 10.1007/s10549-016-3705-3. Epub 2016 Feb 13. Breast Cancer Res Treat. 2016. PMID: 26875184 Free PMC article.
297 results