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Intestinal toxicity to CTLA-4 blockade driven by IL-6 and myeloid infiltration.
Zhou Y, Medik YB, Patel B, Zamler DB, Chen S, Chapman T, Schneider S, Park EM, Babcock RL, Chrisikos TT, Kahn LM, Dyevoich AM, Pineda JE, Wong MC, Mishra AK, Cass SH, Cogdill AP, Johnson DH, Johnson SB, Wani K, Ledesma DA, Hudgens CW, Wang J, Wadud Khan MA, Peterson CB, Joon AY, Peng W, Li HS, Arora R, Tang X, Raso MG, Zhang X, Foo WC, Tetzlaff MT, Diehl GE, Clise-Dwyer K, Whitley EM, Gubin MM, Allison JP, Hwu P, Ajami NJ, Diab A, Wargo JA, Watowich SS. Zhou Y, et al. Among authors: whitley em. J Exp Med. 2023 Feb 6;220(2):e20221333. doi: 10.1084/jem.20221333. Epub 2022 Nov 11. J Exp Med. 2023. PMID: 36367776 Free PMC article.
Telomere dysfunction activates YAP1 to drive tissue inflammation.
Chakravarti D, Hu B, Mao X, Rashid A, Li J, Li J, Liao WT, Whitley EM, Dey P, Hou P, LaBella KA, Chang A, Wang G, Spring DJ, Deng P, Zhao D, Liang X, Lan Z, Lin Y, Sarkar S, Terranova C, Deribe YL, Blutt SE, Okhuysen P, Zhang J, Vilar E, Nielsen OH, Dupont A, Younes M, Patel KR, Shroyer NF, Rai K, Estes MK, Wang YA, Bertuch AA, DePinho RA. Chakravarti D, et al. Among authors: whitley em. Nat Commun. 2020 Sep 21;11(1):4766. doi: 10.1038/s41467-020-18420-w. Nat Commun. 2020. PMID: 32958778 Free PMC article.
A Genetic Mouse Model Recapitulates Immune Checkpoint Inhibitor-Associated Myocarditis and Supports a Mechanism-Based Therapeutic Intervention.
Wei SC, Meijers WC, Axelrod ML, Anang NAS, Screever EM, Wescott EC, Johnson DB, Whitley E, Lehmann L, Courand PY, Mancuso JJ, Himmel LE, Lebrun-Vignes B, Wleklinski MJ, Knollmann BC, Srinivasan J, Li Y, Atolagbe OT, Rao X, Zhao Y, Wang J, Ehrlich LIR, Sharma P, Salem JE, Balko JM, Moslehi JJ, Allison JP. Wei SC, et al. Among authors: whitley e. Cancer Discov. 2021 Mar;11(3):614-625. doi: 10.1158/2159-8290.CD-20-0856. Epub 2020 Nov 30. Cancer Discov. 2021. PMID: 33257470 Free PMC article.
Pathology in Practice.
Behrana Jensen V, Humphreys AF, Pageon LR, Samuels DL, Trimble AL, Mendoza A, Whitley EM. Behrana Jensen V, et al. Among authors: whitley em. J Am Vet Med Assoc. 2022 Mar 1;259(S2):1-4. doi: 10.2460/javma.19.12.0642. J Am Vet Med Assoc. 2022. PMID: 35349477 Free article.
Differential Gain-of-Function Activity of Three p53 Hotspot Mutants In Vivo.
Xiong S, Chachad D, Zhang Y, Gencel-Augusto J, Sirito M, Pant V, Yang P, Sun C, Chau G, Qi Y, Su X, Whitley EM, El-Naggar AK, Lozano G. Xiong S, et al. Among authors: whitley em. Cancer Res. 2022 May 16;82(10):1926-1936. doi: 10.1158/0008-5472.CAN-21-3376. Cancer Res. 2022. PMID: 35320355 Free PMC article.
92 results