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Metabolome-wide association study on ABCA7 indicates a role of ceramide metabolism in Alzheimer's disease.
Dehghan A, Pinto RC, Karaman I, Huang J, Durainayagam BR, Ghanbari M, Nazeer A, Zhong Q, Liggi S, Whiley L, Mustafa R, Kivipelto M, Solomon A, Ngandu T, Kanekiyo T, Aikawa T, Radulescu CI, Barnes SJ, Graça G, Chekmeneva E, Camuzeaux S, Lewis MR, Kaluarachchi MR, Ikram MA, Holmes E, Tzoulaki I, Matthews PM, Griffin JL, Elliott P. Dehghan A, et al. Among authors: whiley l. Proc Natl Acad Sci U S A. 2022 Oct 25;119(43):e2206083119. doi: 10.1073/pnas.2206083119. Epub 2022 Oct 21. Proc Natl Acad Sci U S A. 2022. PMID: 36269859 Free PMC article.
Ultrahigh-Performance Liquid Chromatography Tandem Mass Spectrometry with Electrospray Ionization Quantification of Tryptophan Metabolites and Markers of Gut Health in Serum and Plasma-Application to Clinical and Epidemiology Cohorts.
Whiley L, Nye LC, Grant I, Andreas N, Chappell KE, Sarafian MH, Misra R, Plumb RS, Lewis MR, Nicholson JK, Holmes E, Swann JR, Wilson ID. Whiley L, et al. Anal Chem. 2019 Apr 16;91(8):5207-5216. doi: 10.1021/acs.analchem.8b05884. Epub 2019 Mar 25. Anal Chem. 2019. PMID: 30848589 Free PMC article.
Urinary metabolic phenotyping for Alzheimer's disease.
Kurbatova N, Garg M, Whiley L, Chekmeneva E, Jiménez B, Gómez-Romero M, Pearce J, Kimhofer T, D'Hondt E, Soininen H, Kłoszewska I, Mecocci P, Tsolaki M, Vellas B, Aarsland D, Nevado-Holgado A, Liu B, Snowden S, Proitsi P, Ashton NJ, Hye A, Legido-Quigley C, Lewis MR, Nicholson JK, Holmes E, Brazma A, Lovestone S. Kurbatova N, et al. Among authors: whiley l. Sci Rep. 2020 Dec 10;10(1):21745. doi: 10.1038/s41598-020-78031-9. Sci Rep. 2020. PMID: 33303834 Free PMC article.
Metabolic phenotyping reveals a reduction in the bioavailability of serotonin and kynurenine pathway metabolites in both the urine and serum of individuals living with Alzheimer's disease.
Whiley L, Chappell KE, D'Hondt E, Lewis MR, Jiménez B, Snowden SG, Soininen H, Kłoszewska I, Mecocci P, Tsolaki M, Vellas B, Swann JR, Hye A, Lovestone S, Legido-Quigley C, Holmes E; AddNeuroMed consortium. Whiley L, et al. Alzheimers Res Ther. 2021 Jan 9;13(1):20. doi: 10.1186/s13195-020-00741-z. Alzheimers Res Ther. 2021. PMID: 33422142 Free PMC article.
A targeted ultra performance liquid chromatography - Tandem mass spectrometric assay for tyrosine and metabolites in urine and plasma: Application to the effects of antibiotics on mice.
Letertre MPM, Myridakis A, Whiley L, Camuzeaux S, Lewis MR, Chappell KE, Thaikkatil A, Dumas ME, Nicholson JK, Swann JR, Wilson ID. Letertre MPM, et al. Among authors: whiley l. J Chromatogr B Analyt Technol Biomed Life Sci. 2021 Feb 1;1164:122511. doi: 10.1016/j.jchromb.2020.122511. Epub 2020 Dec 22. J Chromatogr B Analyt Technol Biomed Life Sci. 2021. PMID: 33460909
Tryptophan-metabolizing gut microbes regulate adult neurogenesis via the aryl hydrocarbon receptor.
Wei GZ, Martin KA, Xing PY, Agrawal R, Whiley L, Wood TK, Hejndorf S, Ng YZ, Low JZY, Rossant J, Nechanitzky R, Holmes E, Nicholson JK, Tan EK, Matthews PM, Pettersson S. Wei GZ, et al. Among authors: whiley l. Proc Natl Acad Sci U S A. 2021 Jul 6;118(27):e2021091118. doi: 10.1073/pnas.2021091118. Proc Natl Acad Sci U S A. 2021. PMID: 34210797 Free PMC article.
46 results