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Derivation of metabolic point of departure using high-throughput in vitro metabolomics: investigating the importance of sampling time points on benchmark concentration values in the HepaRG cell line.
Malinowska JM, Palosaari T, Sund J, Carpi D, Weber RJM, Lloyd GR, Whelan M, Viant MR. Malinowska JM, et al. Among authors: whelan m. Arch Toxicol. 2023 Mar;97(3):721-735. doi: 10.1007/s00204-022-03439-3. Epub 2023 Jan 22. Arch Toxicol. 2023. PMID: 36683062 Free PMC article.
Microscopy-based high-throughput assays enable multi-parametric analysis to assess adverse effects of nanomaterials in various cell lines.
Hansjosten I, Rapp J, Reiner L, Vatter R, Fritsch-Decker S, Peravali R, Palosaari T, Joossens E, Gerloff K, Macko P, Whelan M, Gilliland D, Ojea-Jimenez I, Monopoli MP, Rocks L, Garry D, Dawson K, Röttgermann PJF, Murschhauser A, Rädler JO, Tang SVY, Gooden P, Belinga-Desaunay MA, Khan AO, Briffa S, Guggenheim E, Papadiamantis A, Lynch I, Valsami-Jones E, Diabaté S, Weiss C. Hansjosten I, et al. Among authors: whelan m. Arch Toxicol. 2018 Feb;92(2):633-649. doi: 10.1007/s00204-017-2106-7. Epub 2017 Nov 8. Arch Toxicol. 2018. PMID: 29119250
Extrapolating from acute to chronic toxicity in vitro.
Macko P, Palosaari T, Whelan M. Macko P, et al. Among authors: whelan m. Toxicol In Vitro. 2021 Oct;76:105206. doi: 10.1016/j.tiv.2021.105206. Epub 2021 Jun 26. Toxicol In Vitro. 2021. PMID: 34186185 Free PMC article.
Progress towards an OECD reporting framework for transcriptomics and metabolomics in regulatory toxicology.
Harrill JA, Viant MR, Yauk CL, Sachana M, Gant TW, Auerbach SS, Beger RD, Bouhifd M, O'Brien J, Burgoon L, Caiment F, Carpi D, Chen T, Chorley BN, Colbourne J, Corvi R, Debrauwer L, O'Donovan C, Ebbels TMD, Ekman DR, Faulhammer F, Gribaldo L, Hilton GM, Jones SP, Kende A, Lawson TN, Leite SB, Leonards PEG, Luijten M, Martin A, Moussa L, Rudaz S, Schmitz O, Sobanski T, Strauss V, Vaccari M, Vijay V, Weber RJM, Williams AJ, Williams A, Thomas RS, Whelan M. Harrill JA, et al. Among authors: whelan m. Regul Toxicol Pharmacol. 2021 Oct;125:105020. doi: 10.1016/j.yrtph.2021.105020. Epub 2021 Jul 29. Regul Toxicol Pharmacol. 2021. PMID: 34333066 Free PMC article.
514 results