Werz O - Search Results

1

Design, Synthesis, and Pharmacological Characterization of a Potent Soluble Epoxide Hydrolase Inhibitor for the Treatment of Acute Pancreatitis.

Musella S, D'Avino D, Peltner LK, Di Sarno V, Cerqua I, Merciai F, Vestuto V, Ciaglia T, Smaldone G, Di Matteo F, Di Micco S, Napolitano V, Bifulco G, Pepe G, Sommella EM, Basilicata MG, Aquino G, Gomez-Monterrey IM, Campiglia P, Ostacolo C, Roviezzo F, Werz O, Rossi A, Bertamino A. Musella S, et al. Among authors: werz o. J Med Chem. 2023 Jul 13;66(13):9201-9222. doi: 10.1021/acs.jmedchem.3c00831. Epub 2023 Jun 19. J Med Chem. 2023. PMID: 37334504 Free PMC article.

2

Design and synthesis of novel 2-amino-5-hydroxyindole derivatives that inhibit human 5-lipoxygenase.

Landwehr J, George S, Karg EM, Poeckel D, Steinhilber D, Troschuetz R, Werz O. Landwehr J, et al. Among authors: werz o. J Med Chem. 2006 Jul 13;49(14):4327-32. doi: 10.1021/jm050801i. J Med Chem. 2006. PMID: 16821792

3

Structural optimization and biological evaluation of 2-substituted 5-hydroxyindole-3-carboxylates as potent inhibitors of human 5-lipoxygenase.

Karg EM, Luderer S, Pergola C, Bühring U, Rossi A, Northoff H, Sautebin L, Troschütz R, Werz O. Karg EM, et al. Among authors: werz o. J Med Chem. 2009 Jun 11;52(11):3474-83. doi: 10.1021/jm900212y. J Med Chem. 2009. PMID: 19492852 Free article.

4

Discovery of benzo[g]indol-3-carboxylates as potent inhibitors of microsomal prostaglandin E(2) synthase-1.

Koeberle A, Haberl EM, Rossi A, Pergola C, Dehm F, Northoff H, Troschuetz R, Sautebin L, Werz O. Koeberle A, et al. Among authors: werz o. Bioorg Med Chem. 2009 Dec 1;17(23):7924-32. doi: 10.1016/j.bmc.2009.10.025. Epub 2009 Oct 31. Bioorg Med Chem. 2009. PMID: 19884011

5

Structure-based discovery of inhibitors of microsomal prostaglandin E2 synthase-1, 5-lipoxygenase and 5-lipoxygenase-activating protein: promising hits for the development of new anti-inflammatory agents.

De Simone R, Chini MG, Bruno I, Riccio R, Mueller D, Werz O, Bifulco G. De Simone R, et al. Among authors: werz o. J Med Chem. 2011 Mar 24;54(6):1565-75. doi: 10.1021/jm101238d. Epub 2011 Feb 16. J Med Chem. 2011. PMID: 21323313

6

Cinnamyl-3,4-dihydroxy-α-cyanocinnamate is a potent inhibitor of 5-lipoxygenase.

Pergola C, Jazzar B, Rossi A, Buehring U, Luderer S, Dehm F, Northoff H, Sautebin L, Werz O. Pergola C, et al. Among authors: werz o. J Pharmacol Exp Ther. 2011 Jul;338(1):205-13. doi: 10.1124/jpet.111.180794. Epub 2011 Mar 29. J Pharmacol Exp Ther. 2011. PMID: 21447614

7

On the inhibition of 5-lipoxygenase product formation by tryptanthrin: mechanistic studies and efficacy in vivo.

Pergola C, Jazzar B, Rossi A, Northoff H, Hamburger M, Sautebin L, Werz O. Pergola C, et al. Among authors: werz o. Br J Pharmacol. 2012 Feb;165(3):765-76. doi: 10.1111/j.1476-5381.2011.01605.x. Br J Pharmacol. 2012. PMID: 21797843 Free PMC article.

8

Design and synthesis of a second series of triazole-based compounds as potent dual mPGES-1 and 5-lipoxygenase inhibitors.

Chini MG, De Simone R, Bruno I, Riccio R, Dehm F, Weinigel C, Barz D, Werz O, Bifulco G. Chini MG, et al. Among authors: werz o. Eur J Med Chem. 2012 Aug;54:311-23. doi: 10.1016/j.ejmech.2012.05.014. Epub 2012 May 18. Eur J Med Chem. 2012. PMID: 22683242

9

Identification of new γ-hydroxybutenolides that preferentially inhibit the activity of mPGES-1.

De Simone R, Bruno I, Riccio R, Stadler K, Bauer J, Schaible AM, Laufer S, Werz O. De Simone R, et al. Among authors: werz o. Bioorg Med Chem. 2012 Aug 15;20(16):5012-6. doi: 10.1016/j.bmc.2012.06.032. Epub 2012 Jun 23. Bioorg Med Chem. 2012. PMID: 22795900

10

Modified acidic nonsteroidal anti-inflammatory drugs as dual inhibitors of mPGES-1 and 5-LOX.

Elkady M, Nieß R, Schaible AM, Bauer J, Luderer S, Ambrosi G, Werz O, Laufer SA. Elkady M, et al. Among authors: werz o. J Med Chem. 2012 Oct 25;55(20):8958-62. doi: 10.1021/jm3010543. Epub 2012 Oct 9. J Med Chem. 2012. PMID: 22992107

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