Werner T - Search Results

1

Tracking cancer drugs in living cells by thermal profiling of the proteome.

Savitski MM, Reinhard FB, Franken H, Werner T, Savitski MF, Eberhard D, Martinez Molina D, Jafari R, Dovega RB, Klaeger S, Kuster B, Nordlund P, Bantscheff M, Drewes G. Savitski MM, et al. Among authors: werner t. Science. 2014 Oct 3;346(6205):1255784. doi: 10.1126/science.1255784. Epub 2014 Oct 2. Science. 2014. PMID: 25278616

2

A proteome-wide approach identifies sumoylated substrate proteins in yeast.

Panse VG, Hardeland U, Werner T, Kuster B, Hurt E. Panse VG, et al. Among authors: werner t. J Biol Chem. 2004 Oct 1;279(40):41346-51. doi: 10.1074/jbc.M407950200. Epub 2004 Jul 30. J Biol Chem. 2004. PMID: 15292183 Free article.

3

Chemoproteomics-based kinome profiling and target deconvolution of clinical multi-kinase inhibitors in primary chronic lymphocytic leukemia cells.

Kruse U, Pallasch CP, Bantscheff M, Eberhard D, Frenzel L, Ghidelli S, Maier SK, Werner T, Wendtner CM, Drewes G. Kruse U, et al. Among authors: werner t. Leukemia. 2011 Jan;25(1):89-100. doi: 10.1038/leu.2010.233. Epub 2010 Oct 14. Leukemia. 2011. PMID: 20944678

4

A selective inhibitor reveals PI3Kγ dependence of T(H)17 cell differentiation.

Bergamini G, Bell K, Shimamura S, Werner T, Cansfield A, Müller K, Perrin J, Rau C, Ellard K, Hopf C, Doce C, Leggate D, Mangano R, Mathieson T, O'Mahony A, Plavec I, Rharbaoui F, Reinhard F, Savitski MM, Ramsden N, Hirsch E, Drewes G, Rausch O, Bantscheff M, Neubauer G. Bergamini G, et al. Among authors: werner t. Nat Chem Biol. 2012 Apr 29;8(6):576-82. doi: 10.1038/nchembio.957. Nat Chem Biol. 2012. PMID: 22544264

5

High-resolution enabled TMT 8-plexing.

Werner T, Becher I, Sweetman G, Doce C, Savitski MM, Bantscheff M. Werner T, et al. Anal Chem. 2012 Aug 21;84(16):7188-94. doi: 10.1021/ac301553x. Epub 2012 Aug 8. Anal Chem. 2012. PMID: 22881393

6

The commonly used PI3-kinase probe LY294002 is an inhibitor of BET bromodomains.

Dittmann A, Werner T, Chung CW, Savitski MM, Fälth Savitski M, Grandi P, Hopf C, Lindon M, Neubauer G, Prinjha RK, Bantscheff M, Drewes G. Dittmann A, et al. Among authors: werner t. ACS Chem Biol. 2014 Feb 21;9(2):495-502. doi: 10.1021/cb400789e. Epub 2013 Dec 10. ACS Chem Biol. 2014. PMID: 24533473

7

Ion coalescence of neutron encoded TMT 10-plex reporter ions.

Werner T, Sweetman G, Savitski MF, Mathieson T, Bantscheff M, Savitski MM. Werner T, et al. Anal Chem. 2014 Apr 1;86(7):3594-601. doi: 10.1021/ac500140s. Epub 2014 Mar 11. Anal Chem. 2014. PMID: 24579773

8

Thermal proteome profiling for unbiased identification of direct and indirect drug targets using multiplexed quantitative mass spectrometry.

Franken H, Mathieson T, Childs D, Sweetman GM, Werner T, Tögel I, Doce C, Gade S, Bantscheff M, Drewes G, Reinhard FB, Huber W, Savitski MM. Franken H, et al. Among authors: werner t. Nat Protoc. 2015 Oct;10(10):1567-93. doi: 10.1038/nprot.2015.101. Epub 2015 Sep 17. Nat Protoc. 2015. PMID: 26379230

9

Thermal proteome profiling monitors ligand interactions with cellular membrane proteins.

Reinhard FB, Eberhard D, Werner T, Franken H, Childs D, Doce C, Savitski MF, Huber W, Bantscheff M, Savitski MM, Drewes G. Reinhard FB, et al. Among authors: werner t. Nat Methods. 2015 Dec;12(12):1129-31. doi: 10.1038/nmeth.3652. Epub 2015 Nov 2. Nat Methods. 2015. PMID: 26524241

10

A Modular Probe Strategy for Drug Localization, Target Identification and Target Occupancy Measurement on Single Cell Level.

Rutkowska A, Thomson DW, Vappiani J, Werner T, Mueller KM, Dittus L, Krause J, Muelbaier M, Bergamini G, Bantscheff M. Rutkowska A, et al. Among authors: werner t. ACS Chem Biol. 2016 Sep 16;11(9):2541-50. doi: 10.1021/acschembio.6b00346. Epub 2016 Jul 20. ACS Chem Biol. 2016. PMID: 27384741

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