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Intralesional TLR4 agonist treatment strengthens the organ defense against colonizing cancer cells in the brain.
Blazquez R, Chuang HN, Wenske B, Trigueros L, Wlochowitz D, Liguori R, Ferrazzi F, Regen T, Proescholdt MA, Rohde V, Riemenschneider MJ, Stadelmann C, Bleckmann A, Beißbarth T, van Rossum D, Hanisch UK, Pukrop T. Blazquez R, et al. Among authors: wenske b. Oncogene. 2022 Nov;41(46):5008-5019. doi: 10.1038/s41388-022-02496-3. Epub 2022 Oct 12. Oncogene. 2022. PMID: 36224342 Free PMC article.
LEF1 supports metastatic brain colonization by regulating glutathione metabolism and increasing ROS resistance in breast cancer.
Blazquez R, Rietkötter E, Wenske B, Wlochowitz D, Sparrer D, Vollmer E, Müller G, Seegerer J, Sun X, Dettmer K, Barrantes-Freer A, Stange L, Utpatel K, Bleckmann A, Treiber H, Bohnenberger H, Lenz C, Schulz M, Reimelt C, Hackl C, Grade M, Büyüktas D, Siam L, Balkenhol M, Stadelmann C, Kube D, Krahn MP, Proescholdt MA, Riemenschneider MJ, Evert M, Oefner PJ, Klein CA, Hanisch UK, Binder C, Pukrop T. Blazquez R, et al. Among authors: wenske b. Int J Cancer. 2020 Jun 1;146(11):3170-3183. doi: 10.1002/ijc.32742. Epub 2019 Nov 11. Int J Cancer. 2020. PMID: 31626715 Free article.