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Hepatic stellate cells require a stiff environment for myofibroblastic differentiation.
Olsen AL, Bloomer SA, Chan EP, Gaça MD, Georges PC, Sackey B, Uemura M, Janmey PA, Wells RG. Olsen AL, et al. Among authors: wells rg. Am J Physiol Gastrointest Liver Physiol. 2011 Jul;301(1):G110-8. doi: 10.1152/ajpgi.00412.2010. Epub 2011 Apr 28. Am J Physiol Gastrointest Liver Physiol. 2011. PMID: 21527725 Free PMC article.
Smads 2 and 3 are differentially activated by transforming growth factor-beta (TGF-beta ) in quiescent and activated hepatic stellate cells. Constitutive nuclear localization of Smads in activated cells is TGF-beta-independent.
Liu C, Gaça MD, Swenson ES, Vellucci VF, Reiss M, Wells RG. Liu C, et al. Among authors: wells rg. J Biol Chem. 2003 Mar 28;278(13):11721-8. doi: 10.1074/jbc.M207728200. Epub 2003 Jan 22. J Biol Chem. 2003. PMID: 12547835 Free article.
Increased stiffness of the rat liver precedes matrix deposition: implications for fibrosis.
Georges PC, Hui JJ, Gombos Z, McCormick ME, Wang AY, Uemura M, Mick R, Janmey PA, Furth EE, Wells RG. Georges PC, et al. Among authors: wells rg. Am J Physiol Gastrointest Liver Physiol. 2007 Dec;293(6):G1147-54. doi: 10.1152/ajpgi.00032.2007. Epub 2007 Oct 11. Am J Physiol Gastrointest Liver Physiol. 2007. PMID: 17932231 Free article.
308 results