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Senolytics improve physical function and increase lifespan in old age.
Xu M, Pirtskhalava T, Farr JN, Weigand BM, Palmer AK, Weivoda MM, Inman CL, Ogrodnik MB, Hachfeld CM, Fraser DG, Onken JL, Johnson KO, Verzosa GC, Langhi LGP, Weigl M, Giorgadze N, LeBrasseur NK, Miller JD, Jurk D, Singh RJ, Allison DB, Ejima K, Hubbard GB, Ikeno Y, Cubro H, Garovic VD, Hou X, Weroha SJ, Robbins PD, Niedernhofer LJ, Khosla S, Tchkonia T, Kirkland JL. Xu M, et al. Among authors: weigl m. Nat Med. 2018 Aug;24(8):1246-1256. doi: 10.1038/s41591-018-0092-9. Epub 2018 Jul 9. Nat Med. 2018. PMID: 29988130 Free PMC article.
Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis.
Ogrodnik M, Zhu Y, Langhi LGP, Tchkonia T, Krüger P, Fielder E, Victorelli S, Ruswhandi RA, Giorgadze N, Pirtskhalava T, Podgorni O, Enikolopov G, Johnson KO, Xu M, Inman C, Palmer AK, Schafer M, Weigl M, Ikeno Y, Burns TC, Passos JF, von Zglinicki T, Kirkland JL, Jurk D. Ogrodnik M, et al. Among authors: weigl m. Cell Metab. 2019 May 7;29(5):1061-1077.e8. doi: 10.1016/j.cmet.2018.12.008. Epub 2019 Jan 3. Cell Metab. 2019. PMID: 30612898 Free PMC article.
Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis.
Ogrodnik M, Zhu Y, Langhi LGP, Tchkonia T, Krüger P, Fielder E, Victorelli S, Ruswhandi RA, Giorgadze N, Pirtskhalava T, Podgorni O, Enikolopov G, Johnson KO, Xu M, Inman C, Palmer AK, Schafer M, Weigl M, Ikeno Y, Burns TC, Passos JF, von Zglinicki T, Kirkland JL, Jurk D. Ogrodnik M, et al. Among authors: weigl m. Cell Metab. 2019 May 7;29(5):1233. doi: 10.1016/j.cmet.2019.01.013. Cell Metab. 2019. PMID: 31067450 Free PMC article. No abstract available.
miR-146a-5p modulates cellular senescence and apoptosis in visceral adipose tissue of long-lived Ames dwarf mice and in cultured pre-adipocytes.
Nunes ADC, Weigl M, Schneider A, Noureddine S, Yu L, Lahde C, Saccon TD, Mitra K, Beltran E, Grillari J, Kirkland JL, Tchkonia T, Robbins PD, Masternak MM. Nunes ADC, et al. Among authors: weigl m. Geroscience. 2022 Feb;44(1):503-518. doi: 10.1007/s11357-021-00490-3. Epub 2021 Nov 25. Geroscience. 2022. PMID: 34825304 Free PMC article.
Profiling microRNA expression during senescence and aging: mining for a diagnostic tool of senescent-cell burden.
Weigl M, Krammer TL, Pultar M, Wieser M, Chaib S, Suda M, Diendorfer A, Khamina-Kotisch K, Giorgadze N, Pirtskhalava T, Johnson KO, Inman CL, Xue A, Lämmermann I, Meixner B, Wang L, Xu M, Grillari R, Ogrodnik M, Tchkonia T, Hackl M, Kirkland JL, Grillari J. Weigl M, et al. bioRxiv [Preprint]. 2024 Apr 10:2024.04.10.588794. doi: 10.1101/2024.04.10.588794. bioRxiv. 2024. PMID: 38645053 Free PMC article. Preprint.
SVF-derived extracellular vesicles carry characteristic miRNAs in lipedema.
Priglinger E, Strohmeier K, Weigl M, Lindner C, Auer D, Gimona M, Barsch M, Jacak J, Redl H, Grillari J, Sandhofer M, Hackl M, Wolbank S. Priglinger E, et al. Among authors: weigl m. Sci Rep. 2020 Apr 29;10(1):7211. doi: 10.1038/s41598-020-64215-w. Sci Rep. 2020. PMID: 32350368 Free PMC article.
microRNA-146a controls age-related bone loss.
Saferding V, Hofmann M, Brunner JS, Niederreiter B, Timmen M, Magilnick N, Hayer S, Heller G, Steiner G, Stange R, Boldin M, Schabbauer G, Weigl M, Hackl M, Grillari J, Smolen JS, Blüml S. Saferding V, et al. Among authors: weigl m. Aging Cell. 2020 Nov;19(11):e13244. doi: 10.1111/acel.13244. Epub 2020 Oct 21. Aging Cell. 2020. PMID: 33085187 Free PMC article.
198 results