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The clip-segment of the von Willebrand domain 1 of the BMP modulator protein Crossveinless 2 is preformed.
Molecules. 2013 Sep 25;18(10):11658-82. doi: 10.3390/molecules181011658.
Molecules. 2013.
PMID: 24071977
Free PMC article.
NMR structure of the Wnt modulator protein Sclerostin.
Weidauer SE, Schmieder P, Beerbaum M, Schmitz W, Oschkinat H, Mueller TD.
Weidauer SE, et al.
Biochem Biophys Res Commun. 2009 Feb 27;380(1):160-5. doi: 10.1016/j.bbrc.2009.01.062. Epub 2009 Jan 21.
Biochem Biophys Res Commun. 2009.
PMID: 19166819
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Crystal structure analysis reveals how the Chordin family member crossveinless 2 blocks BMP-2 receptor binding.
Zhang JL, Qiu LY, Kotzsch A, Weidauer S, Patterson L, Hammerschmidt M, Sebald W, Mueller TD.
Zhang JL, et al.
Dev Cell. 2008 May;14(5):739-50. doi: 10.1016/j.devcel.2008.02.017.
Dev Cell. 2008.
PMID: 18477456
Free article.
Item in Clipboard
Mutational analysis of sclerostin shows importance of the flexible loop and the cystine-knot for Wnt-signaling inhibition.
Boschert V, van Dinther M, Weidauer S, van Pee K, Muth EM, Ten Dijke P, Mueller TD.
Boschert V, et al.
PLoS One. 2013 Nov 29;8(11):e81710. doi: 10.1371/journal.pone.0081710. eCollection 2013.
PLoS One. 2013.
PMID: 24312339
Free PMC article.
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The sclerostin-neutralizing antibody AbD09097 recognizes an epitope adjacent to sclerostin's binding site for the Wnt co-receptor LRP6.
Boschert V, Frisch C, Back JW, van Pee K, Weidauer SE, Muth EM, Schmieder P, Beerbaum M, Knappik A, Timmerman P, Mueller TD.
Boschert V, et al. Among authors: weidauer se.
Open Biol. 2016 Aug;6(8):160120. doi: 10.1098/rsob.160120.
Open Biol. 2016.
PMID: 27558933
Free PMC article.
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Distinct modes of inhibition by sclerostin on bone morphogenetic protein and Wnt signaling pathways.
Krause C, Korchynskyi O, de Rooij K, Weidauer SE, de Gorter DJ, van Bezooijen RL, Hatsell S, Economides AN, Mueller TD, Löwik CW, ten Dijke P.
Krause C, et al. Among authors: weidauer se.
J Biol Chem. 2010 Dec 31;285(53):41614-26. doi: 10.1074/jbc.M110.153890. Epub 2010 Oct 15.
J Biol Chem. 2010.
PMID: 20952383
Free PMC article.
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Anti-Sclerostin antibody inhibits internalization of Sclerostin and Sclerostin-mediated antagonism of Wnt/LRP6 signaling.
van Dinther M, Zhang J, Weidauer SE, Boschert V, Muth EM, Knappik A, de Gorter DJ, van Kasteren PB, Frisch C, Mueller TD, ten Dijke P.
van Dinther M, et al. Among authors: weidauer se.
PLoS One. 2013 Apr 29;8(4):e62295. doi: 10.1371/journal.pone.0062295. Print 2013.
PLoS One. 2013.
PMID: 23638027
Free PMC article.
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First missense mutation in the SOST gene causing sclerosteosis by loss of sclerostin function.
Piters E, Culha C, Moester M, Van Bezooijen R, Adriaensen D, Mueller T, Weidauer S, Jennes K, de Freitas F, Löwik C, Timmermans JP, Van Hul W, Papapoulos S.
Piters E, et al.
Hum Mutat. 2010 Jul;31(7):E1526-43. doi: 10.1002/humu.21274.
Hum Mutat. 2010.
PMID: 20583295
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