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SEL1L-HRD1 endoplasmic reticulum-associated degradation controls STING-mediated innate immunity by limiting the size of the activable STING pool.
Ji Y, Luo Y, Wu Y, Sun Y, Zhao L, Xue Z, Sun M, Wei X, He Z, Wu SA, Lin LL, Lu Y, Chang L, Chen F, Chen S, Qian W, Xu X, Chen S, Pan D, Zhou Z, Xia S, Hu CA, Liang T, Qi L. Ji Y, et al. Among authors: wei x. Nat Cell Biol. 2023 May;25(5):726-739. doi: 10.1038/s41556-023-01138-4. Epub 2023 May 4. Nat Cell Biol. 2023. PMID: 37142791 Free PMC article.
Endoplasmic reticulum-associated degradation is required for nephrin maturation and kidney glomerular filtration function.
Yoshida S, Wei X, Zhang G, O'Connor CL, Torres M, Zhou Z, Lin L, Menon R, Xu X, Zheng W, Xiong Y, Otto E, Tang CA, Hua R, Verma R, Mori H, Zhang Y, Hu CA, Liu M, Garg P, Hodgin JB, Sun S, Bitzer M, Qi L. Yoshida S, et al. Among authors: wei x. J Clin Invest. 2021 Apr 1;131(7):e143988. doi: 10.1172/JCI143988. J Clin Invest. 2021. PMID: 33591954 Free PMC article.
SEL1L-HRD1 interaction is required to form a functional HRD1 ERAD complex.
Lin LL, Wang HH, Pederson B, Wei X, Torres M, Lu Y, Li ZJ, Liu X, Mao H, Wang H, Zhou LE, Zhao Z, Sun S, Qi L. Lin LL, et al. Among authors: wei x. Nat Commun. 2024 Feb 16;15(1):1440. doi: 10.1038/s41467-024-45633-0. Nat Commun. 2024. PMID: 38365914 Free PMC article.
Generation of a live attenuated influenza A vaccine by proteolysis targeting.
Si L, Shen Q, Li J, Chen L, Shen J, Xiao X, Bai H, Feng T, Ye AY, Li L, Zhang C, Li Z, Wang P, Oh CY, Nurani A, Niu S, Zhang C, Wei X, Yuan W, Liao H, Huang X, Wang N, Tian WX, Tian H, Li L, Liu X, Plebani R. Si L, et al. Among authors: wei x. Nat Biotechnol. 2022 Sep;40(9):1370-1377. doi: 10.1038/s41587-022-01381-4. Epub 2022 Jul 4. Nat Biotechnol. 2022. PMID: 35788567
SerpinB7 deficiency contributes to development of psoriasis via calcium-mediated keratinocyte differentiation dysfunction.
Zheng H, Gu L, Zhao F, Zhang C, Wang Z, Zhou H, Hu Z, Wei X, Liu X, Luo F, Zeng F, Zhao Q, Hao Y, Hu Y, Wang X, Hu J, Yu J, Wu W, Zhou Y, Zhou P, Yue C, Huang N, Cui K, Li W, Li J. Zheng H, et al. Among authors: wei x. Cell Death Dis. 2022 Jul 21;13(7):635. doi: 10.1038/s41419-022-05045-8. Cell Death Dis. 2022. PMID: 35864103 Free PMC article.
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