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Hippo-released WWC1 facilitates AMPA receptor regulatory complexes for hippocampal learning.
Stepan J, Heinz DE, Dethloff F, Bajaj T, Zellner A, Hafner K, Wiechmann S, Mackert S, Mecdad Y, Rabenstein M, Ebert T, Martinelli S, Häusl AS, Pöhlmann ML, Hermann A, Ma X, Pavenstädt H, Schmidt MV, Philipsen A, Turck CW, Deussing JM, Kuster B, Wehr MC, Stein V, Kremerskothen J, Wotjak CT, Gassen NC. Stepan J, et al. Among authors: wehr mc. Cell Rep. 2022 Dec 6;41(10):111766. doi: 10.1016/j.celrep.2022.111766. Cell Rep. 2022. PMID: 36476872 Free article.
Add-on spironolactone as antagonist of the NRG1-ERBB4 signaling pathway for the treatment of schizophrenia: Study design and methodology of a multicenter randomized, placebo-controlled trial.
Hasan A, Roeh A, Leucht S, Langguth B, Hansbauer M, Oviedo-Salcedo T, Kirchner SK, Papazova I, Löhrs L, Wagner E, Maurus I, Strube W, Rossner MJ, Wehr MC, Bauer I, Heres S, Leucht C, Kreuzer PM, Zimmermann S, Schneider-Axmann T, Görlitz T, Karch S, Egert-Schwender S, Schossow B, Rothe P, Falkai P. Hasan A, et al. Among authors: wehr mc. Contemp Clin Trials Commun. 2020 Jan 28;17:100537. doi: 10.1016/j.conctc.2020.100537. eCollection 2020 Mar. Contemp Clin Trials Commun. 2020. PMID: 32072071 Free PMC article.
Evolutionary and molecular facts link the WWC protein family to Hippo signaling.
Wennmann DO, Schmitz J, Wehr MC, Krahn MP, Koschmal N, Gromnitza S, Schulze U, Weide T, Chekuri A, Skryabin BV, Gerke V, Pavenstädt H, Duning K, Kremerskothen J. Wennmann DO, et al. Among authors: wehr mc. Mol Biol Evol. 2014 Jul;31(7):1710-23. doi: 10.1093/molbev/msu115. Epub 2014 Mar 27. Mol Biol Evol. 2014. PMID: 24682284
Inhibiting Hippo pathway kinases releases WWC1 to promote AMPAR-dependent synaptic plasticity and long-term memory in mice.
Stepan J, Heinz DE, Dethloff F, Wiechmann S, Martinelli S, Hafner K, Ebert T, Junglas E, Häusl AS, Pöhlmann ML, Jakovcevski M, Pape JC, Zannas AS, Bajaj T, Hermann A, Ma X, Pavenstädt H, Schmidt MV, Philipsen A, Turck CW, Deussing JM, Rammes G, Robinson AC, Payton A, Wehr MC, Stein V, Murgatroyd C, Kremerskothen J, Kuster B, Wotjak CT, Gassen NC. Stepan J, et al. Among authors: wehr mc. Sci Signal. 2024 Apr 30;17(834):eadj6603. doi: 10.1126/scisignal.adj6603. Epub 2024 Apr 30. Sci Signal. 2024. PMID: 38687825
Multiparametric Assays for Accelerating Early Drug Discovery.
Herholt A, Galinski S, Geyer PE, Rossner MJ, Wehr MC. Herholt A, et al. Among authors: wehr mc. Trends Pharmacol Sci. 2020 May;41(5):318-335. doi: 10.1016/j.tips.2020.02.005. Epub 2020 Mar 27. Trends Pharmacol Sci. 2020. PMID: 32223968 Review.
31 results