Wehner V - Search Results

1

5-Chlorothiophene-2-carboxylic acid [(S)-2-[2-methyl-3-(2-oxopyrrolidin-1-yl)benzenesulfonylamino]-3-(4-methylpiperazin-1-yl)-3-oxopropyl]amide (SAR107375), a selective and potent orally active dual thrombin and factor Xa inhibitor.

Meneyrol J, Follmann M, Lassalle G, Wehner V, Barre G, Rousseaux T, Altenburger JM, Petit F, Bocskei Z, Schreuder H, Alet N, Herault JP, Millet L, Dol F, Florian P, Schaeffer P, Sadoun F, Klieber S, Briot C, Bono F, Herbert JM. Meneyrol J, et al. Among authors: wehner v. J Med Chem. 2013 Dec 12;56(23):9441-56. doi: 10.1021/jm4005835. Epub 2013 Dec 3. J Med Chem. 2013. PMID: 24175584

2

Novel factor Xa inhibitors based on a benzoic acid scaffold and incorporating a neutral P1 ligand.

Nazaré M, Matter H, Klingler O, Al-Obeidi F, Schreuder H, Zoller G, Czech J, Lorenz M, Dudda A, Peyman A, Nestler HP, Urmann M, Bauer A, Laux V, Wehner V, Will DW. Nazaré M, et al. Among authors: wehner v. Bioorg Med Chem Lett. 2004 Jun 7;14(11):2801-5. doi: 10.1016/j.bmcl.2004.03.059. Bioorg Med Chem Lett. 2004. PMID: 15125936

3

Structural requirements for factor Xa inhibition by 3-oxybenzamides with neutral P1 substituents: combining X-ray crystallography, 3D-QSAR, and tailored scoring functions.

Matter H, Will DW, Nazaré M, Schreuder H, Laux V, Wehner V. Matter H, et al. Among authors: wehner v. J Med Chem. 2005 May 5;48(9):3290-312. doi: 10.1021/jm049187l. J Med Chem. 2005. PMID: 15857135

4

Probing the subpockets of factor Xa reveals two binding modes for inhibitors based on a 2-carboxyindole scaffold: a study combining structure-activity relationship and X-ray crystallography.

Nazaré M, Will DW, Matter H, Schreuder H, Ritter K, Urmann M, Essrich M, Bauer A, Wagner M, Czech J, Lorenz M, Laux V, Wehner V. Nazaré M, et al. Among authors: wehner v. J Med Chem. 2005 Jul 14;48(14):4511-25. doi: 10.1021/jm0490540. J Med Chem. 2005. PMID: 15999990

5

Factor Xa inhibitors based on a 2-carboxyindole scaffold: SAR of neutral P1 substituents.

Nazaré M, Essrich M, Will DW, Matter H, Ritter K, Urmann M, Bauer A, Schreuder H, Dudda A, Czech J, Lorenz M, Laux V, Wehner V. Nazaré M, et al. Among authors: wehner v. Bioorg Med Chem Lett. 2004 Aug 16;14(16):4191-5. doi: 10.1016/j.bmcl.2004.06.020. Bioorg Med Chem Lett. 2004. PMID: 15261268

6

Novel factor Xa inhibitors based on a 2-carboxyindole scaffold: SAR of P4 substituents in combination with a neutral P1 ligand.

Nazaré M, Essrich M, Will DW, Matter H, Ritter K, Urmann M, Bauer A, Schreuder H, Czech J, Lorenz M, Laux V, Wehner V. Nazaré M, et al. Among authors: wehner v. Bioorg Med Chem Lett. 2004 Aug 16;14(16):4197-201. doi: 10.1016/j.bmcl.2004.06.019. Bioorg Med Chem Lett. 2004. PMID: 15261269

7

Fragment deconstruction of small, potent factor Xa inhibitors: exploring the superadditivity energetics of fragment linking in protein-ligand complexes.

Nazaré M, Matter H, Will DW, Wagner M, Urmann M, Czech J, Schreuder H, Bauer A, Ritter K, Wehner V. Nazaré M, et al. Among authors: wehner v. Angew Chem Int Ed Engl. 2012 Jan 23;51(4):905-11. doi: 10.1002/anie.201107091. Epub 2011 Dec 21. Angew Chem Int Ed Engl. 2012. PMID: 22190348 No abstract available.

8

Probing Factor Xa Protein-Ligand Interactions: Accurate Free Energy Calculations and Experimental Validations of Two Series of High-Affinity Ligands.

Fernández-Bachiller MI, Hwang S, Schembri ME, Lindemann P, Guberman M, Herziger S, Specker E, Matter H, Will DW, Czech J, Wagner M, Bauer A, Schreuder H, Ritter K, Urmann M, Wehner V, Sun H, Nazaré M. Fernández-Bachiller MI, et al. Among authors: wehner v. J Med Chem. 2022 Oct 13;65(19):13013-13028. doi: 10.1021/acs.jmedchem.2c00865. Epub 2022 Sep 30. J Med Chem. 2022. PMID: 36178213

9

Evidence for C-Cl/C-Br...pi interactions as an important contribution to protein-ligand binding affinity.

Matter H, Nazaré M, Güssregen S, Will DW, Schreuder H, Bauer A, Urmann M, Ritter K, Wagner M, Wehner V. Matter H, et al. Among authors: wehner v. Angew Chem Int Ed Engl. 2009;48(16):2911-6. doi: 10.1002/anie.200806219. Angew Chem Int Ed Engl. 2009. PMID: 19294721

10

Discovery of an orally active non-peptide fibrinogen receptor antagonist based on the hydantoin scaffold.

Stilz HU, Guba W, Jablonka B, Just M, Klingler O, König W, Wehner V, Zoller G. Stilz HU, et al. Among authors: wehner v. J Med Chem. 2001 Apr 12;44(8):1158-76. doi: 10.1021/jm001068s. J Med Chem. 2001. PMID: 11312916

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