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Page 1
Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120).
Sparks SM, Chen G, Collins JL, Danger D, Dock ST, Jayawickreme C, Jenkinson S, Laudeman C, Leesnitzer MA, Liang X, Maloney P, McCoy DC, Moncol D, Rash V, Rimele T, Vulimiri P, Way JM, Ross S. Sparks SM, et al. Among authors: way jm. Bioorg Med Chem Lett. 2014 Jul 15;24(14):3100-3. doi: 10.1016/j.bmcl.2014.05.012. Epub 2014 May 16. Bioorg Med Chem Lett. 2014. PMID: 24881566
Phenoxyacetic acids as PPARδ partial agonists: synthesis, optimization, and in vivo efficacy.
Evans KA, Shearer BG, Wisnoski DD, Shi D, Sparks SM, Sternbach DD, Winegar DA, Billin AN, Britt C, Way JM, Epperly AH, Leesnitzer LM, Merrihew RV, Xu RX, Lambert MH, Jin J. Evans KA, et al. Among authors: way jm. Bioorg Med Chem Lett. 2011 Apr 15;21(8):2345-50. doi: 10.1016/j.bmcl.2011.02.077. Epub 2011 Mar 15. Bioorg Med Chem Lett. 2011. PMID: 21414782
Discovery of 6,7-dihydro-5H-pyrrolo[2,3-a]pyrimidines as orally available G protein-coupled receptor 119 agonists.
Katamreddy SR, Carpenter AJ, Ammala CE, Boros EE, Brashear RL, Briscoe CP, Bullard SR, Caldwell RD, Conlee CR, Croom DK, Hart SM, Heyer DO, Johnson PR, Kashatus JA, Minick DJ, Peckham GE, Ross SA, Roller SG, Samano VA, Sauls HR, Tadepalli SM, Thompson JB, Xu Y, Way JM. Katamreddy SR, et al. Among authors: way jm. J Med Chem. 2012 Dec 27;55(24):10972-94. doi: 10.1021/jm301404a. Epub 2012 Dec 12. J Med Chem. 2012. PMID: 23214471
Discovery of a novel class of PPARdelta partial agonists.
Shearer BG, Patel HS, Billin AN, Way JM, Winegar DA, Lambert MH, Xu RX, Leesnitzer LM, Merrihew RV, Huet S, Willson TM. Shearer BG, et al. Among authors: way jm. Bioorg Med Chem Lett. 2008 Sep 15;18(18):5018-22. doi: 10.1016/j.bmcl.2008.08.011. Epub 2008 Aug 9. Bioorg Med Chem Lett. 2008. PMID: 18722772
Constitutive receptor systems for drug discovery.
Chen G, Jayawickreme C, Way J, Armour S, Queen K, Watson C, Ignar D, Chen WJ, Kenakin T. Chen G, et al. J Pharmacol Toxicol Methods. 1999 Dec;42(4):199-206. doi: 10.1016/s1056-8719(00)00075-7. J Pharmacol Toxicol Methods. 1999. PMID: 11033435
Identification and characterization of 4-chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide (GSK3787), a selective and irreversible peroxisome proliferator-activated receptor delta (PPARdelta) antagonist.
Shearer BG, Wiethe RW, Ashe A, Billin AN, Way JM, Stanley TB, Wagner CD, Xu RX, Leesnitzer LM, Merrihew RV, Shearer TW, Jeune MR, Ulrich JC, Willson TM. Shearer BG, et al. Among authors: way jm. J Med Chem. 2010 Feb 25;53(4):1857-61. doi: 10.1021/jm900464j. J Med Chem. 2010. PMID: 20128594
The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids.
Briscoe CP, Tadayyon M, Andrews JL, Benson WG, Chambers JK, Eilert MM, Ellis C, Elshourbagy NA, Goetz AS, Minnick DT, Murdock PR, Sauls HR Jr, Shabon U, Spinage LD, Strum JC, Szekeres PG, Tan KB, Way JM, Ignar DM, Wilson S, Muir AI. Briscoe CP, et al. Among authors: way jm. J Biol Chem. 2003 Mar 28;278(13):11303-11. doi: 10.1074/jbc.M211495200. Epub 2002 Dec 19. J Biol Chem. 2003. PMID: 12496284 Free article.
27 results