Watanabe S - Search Results

1

Zika Virus NS5 Forms Supramolecular Nuclear Bodies That Sequester Importin-α and Modulate the Host Immune and Pro-Inflammatory Response in Neuronal Cells.

Ng IHW, Chan KW, Tan MJA, Gwee CP, Smith KM, Jeffress SJ, Saw WG, Swarbrick CMD, Watanabe S, Jans DA, Grüber G, Forwood JK, Vasudevan SG. Ng IHW, et al. Among authors: watanabe s. ACS Infect Dis. 2019 Jun 14;5(6):932-948. doi: 10.1021/acsinfecdis.8b00373. Epub 2019 Mar 19. ACS Infect Dis. 2019. PMID: 30848123

2

Celgosivir treatment misfolds dengue virus NS1 protein, induces cellular pro-survival genes and protects against lethal challenge mouse model.

Rathore AP, Paradkar PN, Watanabe S, Tan KH, Sung C, Connolly JE, Low J, Ooi EE, Vasudevan SG. Rathore AP, et al. Among authors: watanabe s. Antiviral Res. 2011 Dec;92(3):453-60. doi: 10.1016/j.antiviral.2011.10.002. Epub 2011 Oct 12. Antiviral Res. 2011. PMID: 22020302

3

The magnitude of dengue virus NS1 protein secretion is strain dependent and does not correlate with severe pathologies in the mouse infection model.

Watanabe S, Tan KH, Rathore AP, Rozen-Gagnon K, Shuai W, Ruedl C, Vasudevan SG. Watanabe S, et al. J Virol. 2012 May;86(10):5508-14. doi: 10.1128/JVI.07081-11. Epub 2012 Mar 14. J Virol. 2012. PMID: 22419801 Free PMC article.

4

Dose- and schedule-dependent protective efficacy of celgosivir in a lethal mouse model for dengue virus infection informs dosing regimen for a proof of concept clinical trial.

Watanabe S, Rathore AP, Sung C, Lu F, Khoo YM, Connolly J, Low J, Ooi EE, Lee HS, Vasudevan SG. Watanabe S, et al. Antiviral Res. 2012 Oct;96(1):32-5. doi: 10.1016/j.antiviral.2012.07.008. Epub 2012 Jul 31. Antiviral Res. 2012. PMID: 22867971

5

Cell-based flavivirus infection (CFI) assay for the evaluation of dengue antiviral candidates using high-content imaging.

Tan KH, Ki KC, Watanabe S, Vasudevan SG, Krishnan M. Tan KH, et al. Among authors: watanabe s. Methods Mol Biol. 2014;1138:99-109. doi: 10.1007/978-1-4939-0348-1_7. Methods Mol Biol. 2014. PMID: 24696333

6

Evaluation of dengue antiviral candidates in vivo in mouse model.

Watanabe S, Vasudevan SG. Watanabe S, et al. Methods Mol Biol. 2014;1138:391-400. doi: 10.1007/978-1-4939-0348-1_24. Methods Mol Biol. 2014. PMID: 24696350

7

Efficacy and safety of celgosivir in patients with dengue fever (CELADEN): a phase 1b, randomised, double-blind, placebo-controlled, proof-of-concept trial.

Low JG, Sung C, Wijaya L, Wei Y, Rathore APS, Watanabe S, Tan BH, Toh L, Chua LT, Hou Y, Chow A, Howe S, Chan WK, Tan KH, Chung JS, Cherng BP, Lye DC, Tambayah PA, Ng LC, Connolly J, Hibberd ML, Leo YS, Cheung YB, Ooi EE, Vasudevan SG. Low JG, et al. Among authors: watanabe s. Lancet Infect Dis. 2014 Aug;14(8):706-715. doi: 10.1016/S1473-3099(14)70730-3. Epub 2014 May 28. Lancet Infect Dis. 2014. PMID: 24877997 Clinical Trial.

8

A nuclear transport inhibitor that modulates the unfolded protein response and provides in vivo protection against lethal dengue virus infection.

Fraser JE, Watanabe S, Wang C, Chan WK, Maher B, Lopez-Denman A, Hick C, Wagstaff KM, Mackenzie JM, Sexton PM, Vasudevan SG, Jans DA. Fraser JE, et al. Among authors: watanabe s. J Infect Dis. 2014 Dec 1;210(11):1780-91. doi: 10.1093/infdis/jiu319. Epub 2014 Jun 5. J Infect Dis. 2014. PMID: 24903662

9

Dengue Virus Infection with Highly Neutralizing Levels of Cross-Reactive Antibodies Causes Acute Lethal Small Intestinal Pathology without a High Level of Viremia in Mice.

Watanabe S, Chan KW, Wang J, Rivino L, Lok SM, Vasudevan SG. Watanabe S, et al. J Virol. 2015 Jun;89(11):5847-61. doi: 10.1128/JVI.00216-15. Epub 2015 Mar 18. J Virol. 2015. PMID: 25787279 Free PMC article.

10

Animal models for studying dengue pathogenesis and therapy.

Chan KW, Watanabe S, Kavishna R, Alonso S, Vasudevan SG. Chan KW, et al. Among authors: watanabe s. Antiviral Res. 2015 Nov;123:5-14. doi: 10.1016/j.antiviral.2015.08.013. Epub 2015 Aug 21. Antiviral Res. 2015. PMID: 26304704 Review.

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