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Ursodeoxycholic acid stimulates Nrf2-mediated hepatocellular transport, detoxification, and antioxidative stress systems in mice.
Okada K, Shoda J, Taguchi K, Maher JM, Ishizaki K, Inoue Y, Ohtsuki M, Goto N, Takeda K, Utsunomiya H, Oda K, Warabi E, Ishii T, Osaka K, Hyodo I, Yamamoto M. Okada K, et al. Among authors: warabi e. Am J Physiol Gastrointest Liver Physiol. 2008 Oct;295(4):G735-47. doi: 10.1152/ajpgi.90321.2008. Epub 2008 Aug 7. Am J Physiol Gastrointest Liver Physiol. 2008. PMID: 18687751 Free article.
p62/SQSTM1 and Nrf2 are essential for exercise-mediated enhancement of antioxidant protein expression in oxidative muscle.
Yamada M, Iwata M, Warabi E, Oishi H, Lira VA, Okutsu M. Yamada M, et al. Among authors: warabi e. FASEB J. 2019 Jul;33(7):8022-8032. doi: 10.1096/fj.201900133R. Epub 2019 Mar 26. FASEB J. 2019. PMID: 30913396
Interestingly, skeletal muscle-specific loss of p62 (i.e., p62 mKO mice) also abolished the expression of NQO1 and reduced exercise-mediated increases of the same antioxidants in soleus muscle. Collectively, these findings indicate that p62 and Nrf2 cooperatively regulate …
Interestingly, skeletal muscle-specific loss of p62 (i.e., p62 mKO mice) also abolished the expression of NQO1 and reduced exercise-m …
Nrf2 counteracts cholestatic liver injury via stimulation of hepatic defense systems.
Okada K, Shoda J, Taguchi K, Maher JM, Ishizaki K, Inoue Y, Ohtsuki M, Goto N, Sugimoto H, Utsunomiya H, Oda K, Warabi E, Ishii T, Yamamoto M. Okada K, et al. Among authors: warabi e. Biochem Biophys Res Commun. 2009 Nov 20;389(3):431-6. doi: 10.1016/j.bbrc.2009.08.156. Epub 2009 Sep 2. Biochem Biophys Res Commun. 2009. PMID: 19732748
80 results