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NRF2 activators inhibit influenza A virus replication by interfering with nucleo-cytoplasmic export of viral RNPs in an NRF2-independent manner.
Waqas FH, Shehata M, Elgaher WAM, Lacour A, Kurmasheva N, Begnini F, Kiib AE, Dahlmann J, Chen C, Pavlou A, Poulsen TB, Merkert S, Martin U, Olmer R, Olagnier D, Hirsch AKH, Pleschka S, Pessler F. Waqas FH, et al. PLoS Pathog. 2023 Jul 17;19(7):e1011506. doi: 10.1371/journal.ppat.1011506. eCollection 2023 Jul. PLoS Pathog. 2023. PMID: 37459366 Free PMC article.
Citraconate inhibits ACOD1 (IRG1) catalysis, reduces interferon responses and oxidative stress, and modulates inflammation and cell metabolism.
Chen F, Elgaher WAM, Winterhoff M, Büssow K, Waqas FH, Graner E, Pires-Afonso Y, Casares Perez L, de la Vega L, Sahini N, Czichon L, Zobl W, Zillinger T, Shehata M, Pleschka S, Bähre H, Falk C, Michelucci A, Schuchardt S, Blankenfeldt W, Hirsch AKH, Pessler F. Chen F, et al. Among authors: waqas fh. Nat Metab. 2022 May;4(5):534-546. doi: 10.1038/s42255-022-00577-x. Epub 2022 Jun 2. Nat Metab. 2022. PMID: 35655026 Free PMC article.