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Identification of a Protein Arginine Methyltransferase 7 (PRMT7)/Protein Arginine Methyltransferase 9 (PRMT9) Inhibitor.
Feoli A, Iannelli G, Cipriano A, Milite C, Shen L, Wang Z, Hadjikyriacou A, Lowe TL, Safaeipour C, Viviano M, Sarno G, Morretta E, Monti MC, Yang Y, Clarke SG, Cosconati S, Castellano S, Sbardella G. Feoli A, et al. Among authors: wang z. J Med Chem. 2023 Oct 12;66(19):13665-13683. doi: 10.1021/acs.jmedchem.3c01030. Epub 2023 Aug 10. J Med Chem. 2023. PMID: 37560786 Free PMC article.
TDRD3 promotes DHX9 chromatin recruitment and R-loop resolution.
Yuan W, Al-Hadid Q, Wang Z, Shen L, Cho H, Wu X, Yang Y. Yuan W, et al. Among authors: wang z. Nucleic Acids Res. 2021 Sep 7;49(15):8573-8591. doi: 10.1093/nar/gkab642. Nucleic Acids Res. 2021. PMID: 34329467 Free PMC article.
Loss-of-function mutation in PRMT9 causes abnormal synapse development by dysregulation of RNA alternative splicing.
Shen L, Ma X, Wang Y, Wang Z, Zhang Y, Pham HQH, Tao X, Cui Y, Wei J, Lin D, Abeywanada T, Hardikar S, Halabelian L, Smith N, Chen T, Barsyte-Lovejoy D, Qiu S, Xing Y, Yang Y. Shen L, et al. Among authors: wang z, wang y. Nat Commun. 2024 Apr 1;15(1):2809. doi: 10.1038/s41467-024-47107-9. Nat Commun. 2024. PMID: 38561334 Free PMC article.
Targeting PRMT1-mediated FLT3 methylation disrupts maintenance of MLL-rearranged acute lymphoblastic leukemia.
Zhu Y, He X, Lin YC, Dong H, Zhang L, Chen X, Wang Z, Shen Y, Li M, Wang H, Sun J, Nguyen LX, Zhang H, Jiang W, Yang Y, Chen J, Müschen M, Chen CW, Konopleva MY, Sun W, Jin J, Carlesso N, Marcucci G, Luo Y, Li L. Zhu Y, et al. Among authors: wang h, wang z. Blood. 2019 Oct 10;134(15):1257-1268. doi: 10.1182/blood.2019002457. Blood. 2019. PMID: 31395602 Free PMC article.
PRMT1-mediated FLT3 arginine methylation promotes maintenance of FLT3-ITD+ acute myeloid leukemia.
He X, Zhu Y, Lin YC, Li M, Du J, Dong H, Sun J, Zhu L, Wang H, Ding Z, Zhang L, Zhang L, Zhao D, Wang Z, Wu H, Zhang H, Jiang W, Xu Y, Jin J, Shen Y, Perry J, Zhao X, Zhang B, Liu S, Xue SL, Shen B, Chen CW, Chen J, Khaled S, Kuo YH, Marcucci G, Luo Y, Li L. He X, et al. Among authors: wang h, wang z. Blood. 2019 Aug 8;134(6):548-560. doi: 10.1182/blood.2019001282. Epub 2019 Jun 19. Blood. 2019. PMID: 31217189 Free PMC article.
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