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Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression.
Wray NR, Ripke S, Mattheisen M, Trzaskowski M, Byrne EM, Abdellaoui A, Adams MJ, Agerbo E, Air TM, Andlauer TMF, Bacanu SA, Bækvad-Hansen M, Beekman AFT, Bigdeli TB, Binder EB, Blackwood DRH, Bryois J, Buttenschøn HN, Bybjerg-Grauholm J, Cai N, Castelao E, Christensen JH, Clarke TK, Coleman JIR, Colodro-Conde L, Couvy-Duchesne B, Craddock N, Crawford GE, Crowley CA, Dashti HS, Davies G, Deary IJ, Degenhardt F, Derks EM, Direk N, Dolan CV, Dunn EC, Eley TC, Eriksson N, Escott-Price V, Kiadeh FHF, Finucane HK, Forstner AJ, Frank J, Gaspar HA, Gill M, Giusti-Rodríguez P, Goes FS, Gordon SD, Grove J, Hall LS, Hannon E, Hansen CS, Hansen TF, Herms S, Hickie IB, Hoffmann P, Homuth G, Horn C, Hottenga JJ, Hougaard DM, Hu M, Hyde CL, Ising M, Jansen R, Jin F, Jorgenson E, Knowles JA, Kohane IS, Kraft J, Kretzschmar WW, Krogh J, Kutalik Z, Lane JM, Li Y, Li Y, Lind PA, Liu X, Lu L, MacIntyre DJ, MacKinnon DF, Maier RM, Maier W, Marchini J, Mbarek H, McGrath P, McGuffin P, Medland SE, Mehta D, Middeldorp CM, Mihailov E, Milaneschi Y, Milani L, Mill J, Mondimore FM, Montgomery GW, Mostafavi S, Mullins N, Nauck M, Ng B, Nivard MG, Nyholt DR, O'Reilly PF, Oskarsson H, Owen MJ, Painter JN, Pede… See abstract for full author list ➔ Wray NR, et al. Among authors: wang y. Nat Genet. 2018 May;50(5):668-681. doi: 10.1038/s41588-018-0090-3. Epub 2018 Apr 26. Nat Genet. 2018. PMID: 29700475 Free PMC article.
Identifying common genetic variants in blood pressure due to polygenic pleiotropy with associated phenotypes.
Andreassen OA, McEvoy LK, Thompson WK, Wang Y, Reppe S, Schork AJ, Zuber V, Barrett-Connor E, Gautvik K, Aukrust P, Karlsen TH, Djurovic S, Desikan RS, Dale AM; International Consortium for Blood Pressure Genome-Wide Association Studies, Genetic Factors for Osteoporosis Consortium. Andreassen OA, et al. Among authors: wang y. Hypertension. 2014 Apr;63(4):819-26. doi: 10.1161/HYPERTENSIONAHA.113.02077. Epub 2014 Jan 6. Hypertension. 2014. PMID: 24396023 Free PMC article.
Abundant genetic overlap between blood lipids and immune-mediated diseases indicates shared molecular genetic mechanisms.
Andreassen OA, Desikan RS, Wang Y, Thompson WK, Schork AJ, Zuber V, Doncheva NT, Ellinghaus E, Albrecht M, Mattingsdal M, Franke A, Lie BA, Mills IG, Aukrust P, McEvoy LK, Djurovic S, Karlsen TH, Dale AM. Andreassen OA, et al. Among authors: wang y. PLoS One. 2015 Apr 8;10(4):e0123057. doi: 10.1371/journal.pone.0123057. eCollection 2015. PLoS One. 2015. PMID: 25853426 Free PMC article.
Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease.
Desikan RS, Schork AJ, Wang Y, Thompson WK, Dehghan A, Ridker PM, Chasman DI, McEvoy LK, Holland D, Chen CH, Karow DS, Brewer JB, Hess CP, Williams J, Sims R, O'Donovan MC, Choi SH, Bis JC, Ikram MA, Gudnason V, DeStefano AL, van der Lee SJ, Psaty BM, van Duijn CM, Launer L, Seshadri S, Pericak-Vance MA, Mayeux R, Haines JL, Farrer LA, Hardy J, Ulstein ID, Aarsland D, Fladby T, White LR, Sando SB, Rongve A, Witoelar A, Djurovic S, Hyman BT, Snaedal J, Steinberg S, Stefansson H, Stefansson K, Schellenberg GD, Andreassen OA, Dale AM; Inflammation working group, IGAP and DemGene Investigators. Desikan RS, et al. Among authors: wang y. Circulation. 2015 Jun 9;131(23):2061-2069. doi: 10.1161/CIRCULATIONAHA.115.015489. Epub 2015 Apr 10. Circulation. 2015. PMID: 25862742 Free PMC article.
Large-scale genomics unveil polygenic architecture of human cortical surface area.
Chen CH, Peng Q, Schork AJ, Lo MT, Fan CC, Wang Y, Desikan RS, Bettella F, Hagler DJ; Pediatric Imaging, Neurocognition and Genetics Study; Alzheimer’s Disease Neuroimaging Initiative; Westlye LT, Kremen WS, Jernigan TL, Le Hellard S, Steen VM, Espeseth T, Huentelman M, Håberg AK, Agartz I, Djurovic S, Andreassen OA, Schork N, Dale AM; Pediatric Imaging Neurocognition and Genetics Study; Alzheimer's Disease Neuroimaging Initiative. Chen CH, et al. Among authors: wang y. Nat Commun. 2015 Jul 20;6:7549. doi: 10.1038/ncomms8549. Nat Commun. 2015. PMID: 26189703 Free PMC article.
Identifying Novel Gene Variants in Coronary Artery Disease and Shared Genes With Several Cardiovascular Risk Factors.
LeBlanc M, Zuber V, Andreassen BK, Witoelar A, Zeng L, Bettella F, Wang Y, McEvoy LK, Thompson WK, Schork AJ, Reppe S, Barrett-Connor E, Ligthart S, Dehghan A, Gautvik KM, Nelson CP, Schunkert H, Samani NJ; CARDIoGRAM Consortium; Ridker PM, Chasman DI, Aukrust P, Djurovic S, Frigessi A, Desikan RS, Dale AM, Andreassen OA. LeBlanc M, et al. Among authors: wang y. Circ Res. 2016 Jan 8;118(1):83-94. doi: 10.1161/CIRCRESAHA.115.306629. Epub 2015 Oct 20. Circ Res. 2016. PMID: 26487741 Free PMC article.
Genetic Markers of Human Evolution Are Enriched in Schizophrenia.
Srinivasan S, Bettella F, Mattingsdal M, Wang Y, Witoelar A, Schork AJ, Thompson WK, Zuber V; Schizophrenia Working Group of the Psychiatric Genomics Consortium, The International Headache Genetics Consortium; Winsvold BS, Zwart JA, Collier DA, Desikan RS, Melle I, Werge T, Dale AM, Djurovic S, Andreassen OA. Srinivasan S, et al. Among authors: wang y. Biol Psychiatry. 2016 Aug 15;80(4):284-292. doi: 10.1016/j.biopsych.2015.10.009. Epub 2015 Oct 21. Biol Psychiatry. 2016. PMID: 26681495 Free PMC article.
Genetic Sharing with Cardiovascular Disease Risk Factors and Diabetes Reveals Novel Bone Mineral Density Loci.
Reppe S, Wang Y, Thompson WK, McEvoy LK, Schork AJ, Zuber V, LeBlanc M, Bettella F, Mills IG, Desikan RS, Djurovic S, Gautvik KM, Dale AM, Andreassen OA; GEFOS Consortium. Reppe S, et al. Among authors: wang y. PLoS One. 2015 Dec 22;10(12):e0144531. doi: 10.1371/journal.pone.0144531. eCollection 2015. PLoS One. 2015. PMID: 26695485 Free PMC article.
An Empirical Bayes Mixture Model for Effect Size Distributions in Genome-Wide Association Studies.
Thompson WK, Wang Y, Schork AJ, Witoelar A, Zuber V, Xu S, Werge T, Holland D; Schizophrenia Working Group of the Psychiatric Genomics Consortium; Andreassen OA, Dale AM. Thompson WK, et al. Among authors: wang y. PLoS Genet. 2015 Dec 29;11(12):e1005717. doi: 10.1371/journal.pgen.1005717. eCollection 2015 Dec. PLoS Genet. 2015. PMID: 26714184 Free PMC article.
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