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DSCAM/PAK1 pathway suppression reverses neurogenesis deficits in iPSC-derived cerebral organoids from patients with Down syndrome.
Tang XY, Xu L, Wang J, Hong Y, Wang Y, Zhu Q, Wang D, Zhang XY, Liu CY, Fang KH, Han X, Wang S, Wang X, Xu M, Bhattacharyya A, Guo X, Lin M, Liu Y. Tang XY, et al. Among authors: wang x, wang j, wang y, wang d, wang s. J Clin Invest. 2021 Jun 15;131(12):e135763. doi: 10.1172/JCI135763. J Clin Invest. 2021. PMID: 33945512 Free PMC article.
The deubiquitinase USP6 affects memory and synaptic plasticity through modulating NMDA receptor stability.
Zeng F, Ma X, Zhu L, Xu Q, Zeng Y, Gao Y, Li G, Guo T, Zhang H, Tang X, Wang Z, Ye Z, Zheng L, Zhang H, Zheng Q, Li K, Lu J, Qi X, Luo H, Zhang X, Wang Z, Zhou Y, Yao Y, Ke R, Zhou Y, Liu Y, Sun H, Huang T, Shao Z, Xu H, Wang X. Zeng F, et al. Among authors: wang x, wang z. PLoS Biol. 2019 Dec 16;17(12):e3000525. doi: 10.1371/journal.pbio.3000525. eCollection 2019 Dec. PLoS Biol. 2019. PMID: 31841517 Free PMC article.
RPS23RG1 Is Required for Synaptic Integrity and Rescues Alzheimer's Disease-Associated Cognitive Deficits.
Zhao D, Meng J, Zhao Y, Huo Y, Liu Y, Zheng N, Zhang M, Gao Y, Chen Z, Sun H, Wang X, Jing C, Zhang T, Zhang X, Luo H, Wang X, Zhang J, Liu FR, Li Y, Bu G, Wen L, Huang TY, Xu H, Zhang YW. Zhao D, et al. Among authors: wang x. Biol Psychiatry. 2019 Aug 1;86(3):171-184. doi: 10.1016/j.biopsych.2018.08.009. Epub 2018 Aug 25. Biol Psychiatry. 2019. PMID: 30292394 Free PMC article.
β2-microglobulin functions as an endogenous NMDAR antagonist to impair synaptic function.
Gao Y, Hong Y, Huang L, Zheng S, Zhang H, Wang S, Yao Y, Zhao Y, Zhu L, Xu Q, Chai X, Zeng Y, Zeng Y, Zheng L, Zhou Y, Luo H, Zhang X, Zhang H, Zhou Y, Fu G, Sun H, Huang TY, Zheng Q, Xu H, Wang X. Gao Y, et al. Among authors: wang x, wang s. Cell. 2023 Mar 2;186(5):1026-1038.e20. doi: 10.1016/j.cell.2023.01.021. Cell. 2023. PMID: 36868208
Activation of FAK/Rac1/Cdc42-GTPase signaling ameliorates impaired microglial migration response to Aβ42 in triggering receptor expressed on myeloid cells 2 loss-of-function murine models.
Rong Z, Cheng B, Zhong L, Ye X, Li X, Jia L, Li Y, Shue F, Wang N, Cheng Y, Huang X, Liu CC, Fryer JD, Wang X, Zhang YW, Zheng H. Rong Z, et al. Among authors: wang x, wang n. FASEB J. 2020 Aug;34(8):10984-10997. doi: 10.1096/fj.202000550RR. Epub 2020 Jul 1. FASEB J. 2020. PMID: 32613609
Minocycline protects against microgliopathy in a Csf1r haplo-insufficient mouse model of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP).
Li X, Hu B, Guan X, Wang Z, Zhou Y, Sun H, Zhang X, Li Y, Huang X, Zhao Y, Wang X, Xu H, Zhang YW, Wang Z, Zheng H. Li X, et al. Among authors: wang x, wang z. J Neuroinflammation. 2023 May 31;20(1):134. doi: 10.1186/s12974-023-02774-1. J Neuroinflammation. 2023. PMID: 37259140 Free PMC article.
TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway.
Zheng H, Jia L, Liu CC, Rong Z, Zhong L, Yang L, Chen XF, Fryer JD, Wang X, Zhang YW, Xu H, Bu G. Zheng H, et al. Among authors: wang x. J Neurosci. 2017 Feb 15;37(7):1772-1784. doi: 10.1523/JNEUROSCI.2459-16.2017. Epub 2017 Jan 11. J Neurosci. 2017. PMID: 28077724 Free PMC article.
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