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Autophagy impairment with lysosomal and mitochondrial dysfunction is an important characteristic of oxidative stress-induced senescence.
Tai H, Wang Z, Gong H, Han X, Zhou J, Wang X, Wei X, Ding Y, Huang N, Qin J, Zhang J, Wang S, Gao F, Chrzanowska-Lightowlers ZM, Xiang R, Xiao H. Tai H, et al. Among authors: wang x, wang z, wang s. Autophagy. 2017 Jan 2;13(1):99-113. doi: 10.1080/15548627.2016.1247143. Epub 2016 Oct 28. Autophagy. 2017. PMID: 27791464 Free PMC article.
Protein kinase Cβ activates fat mass and obesity-associated protein by influencing its ubiquitin/proteasome degradation.
Tai H, Wang X, Zhou J, Han X, Fang T, Gong H, Huang N, Chen H, Qin J, Yang M, Wei X, Yang L, Xiao H. Tai H, et al. Among authors: wang x. FASEB J. 2017 Oct;31(10):4396-4406. doi: 10.1096/fj.201601159RR. Epub 2017 Jun 16. FASEB J. 2017. PMID: 28626026
We propose that PKCbeta acts to suppress the degradation of FTO protein and reveals the associated role of PKCbeta and FTO in adipogenesis, suggesting a new pathway that affects the development of obesity and metabolic diseases.-Tai, H., Wang, X., Zhou, J., Han, …
We propose that PKCbeta acts to suppress the degradation of FTO protein and reveals the associated role of PKCbeta and FTO in adipogenesis, …
Role of AMPK mediated pathways in autophagy and aging.
Ge Y, Zhou M, Chen C, Wu X, Wang X. Ge Y, et al. Among authors: wang x. Biochimie. 2022 Apr;195:100-113. doi: 10.1016/j.biochi.2021.11.008. Epub 2021 Nov 24. Biochimie. 2022. PMID: 34838647 Review.
Amonafide Induces HUVEC Senescence by Inhibiting Autophagy.
Xia J, Zhou Y, He S, Vashisth MK, Jia H, Dai Q, He Y, Wang X. Xia J, et al. Among authors: wang x. Discov Med. 2023 Jun;35(176):264-274. doi: 10.24976/Discov.Med.202335176.27. Discov Med. 2023. PMID: 37272093
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