Wang X - Search Results

1

Inhibition of proteasome deubiquitinase activity: a strategy to overcome resistance to conventional proteasome inhibitors?

Selvaraju K, Mazurkiewicz M, Wang X, Gullbo J, Linder S, D'Arcy P. Selvaraju K, et al. Among authors: wang x. Drug Resist Updat. 2015 Jul-Aug;21-22:20-9. doi: 10.1016/j.drup.2015.06.001. Epub 2015 Jul 6. Drug Resist Updat. 2015. PMID: 26183292 Free article. Review.

2

The 19S Deubiquitinase inhibitor b-AP15 is enriched in cells and elicits rapid commitment to cell death.

Wang X, Stafford W, Mazurkiewicz M, Fryknäs M, Brjnic S, Zhang X, Gullbo J, Larsson R, Arnér ES, D'Arcy P, Linder S. Wang X, et al. Mol Pharmacol. 2014 Jun;85(6):932-45. doi: 10.1124/mol.113.091322. Epub 2014 Apr 8. Mol Pharmacol. 2014. PMID: 24714215

3

Deubiquitinase inhibition as a cancer therapeutic strategy.

D'Arcy P, Wang X, Linder S. D'Arcy P, et al. Among authors: wang x. Pharmacol Ther. 2015 Mar;147:32-54. doi: 10.1016/j.pharmthera.2014.11.002. Epub 2014 Nov 6. Pharmacol Ther. 2015. PMID: 25444757 Free article. Review.

4

Synthesis and evaluation of derivatives of the proteasome deubiquitinase inhibitor b-AP15.

Wang X, D'Arcy P, Caulfield TR, Paulus A, Chitta K, Mohanty C, Gullbo J, Chanan-Khan A, Linder S. Wang X, et al. Chem Biol Drug Des. 2015 Nov;86(5):1036-48. doi: 10.1111/cbdd.12571. Epub 2015 May 27. Chem Biol Drug Des. 2015. PMID: 25854145 Free PMC article.

5

The proteasome deubiquitinase inhibitor VLX1570 shows selectivity for ubiquitin-specific protease-14 and induces apoptosis of multiple myeloma cells.

Wang X, Mazurkiewicz M, Hillert EK, Olofsson MH, Pierrou S, Hillertz P, Gullbo J, Selvaraju K, Paulus A, Akhtar S, Bossler F, Khan AC, Linder S, D'Arcy P. Wang X, et al. Sci Rep. 2016 Jun 6;6:26979. doi: 10.1038/srep26979. Sci Rep. 2016. PMID: 27264969 Free PMC article.

6

Acute lymphoblastic leukemia cells are sensitive to disturbances in protein homeostasis induced by proteasome deubiquitinase inhibition.

Mazurkiewicz M, Hillert EK, Wang X, Pellegrini P, Olofsson MH, Selvaraju K, D'Arcy P, Linder S. Mazurkiewicz M, et al. Among authors: wang x. Oncotarget. 2017 Mar 28;8(13):21115-21127. doi: 10.18632/oncotarget.15501. Oncotarget. 2017. PMID: 28423502 Free PMC article.

7

Screening for phenotype selective activity in multidrug resistant cells identifies a novel tubulin active agent insensitive to common forms of cancer drug resistance.

Fryknäs M, Gullbo J, Wang X, Rickardson L, Jarvius M, Wickström M, Hassan S, Andersson C, Gustafsson M, Westman G, Nygren P, Linder S, Larsson R. Fryknäs M, et al. Among authors: wang x. BMC Cancer. 2013 Aug 6;13:374. doi: 10.1186/1471-2407-13-374. BMC Cancer. 2013. PMID: 23919498 Free PMC article.

8

Elevation of proteasomal substrate levels sensitizes cells to apoptosis induced by inhibition of proteasomal deubiquitinases.

Sun C, Roboti P, Puumalainen MR, Fryknäs M, Wang X, D'Arcy P, Hult M, High S, Linder S, Swanton E. Sun C, et al. Among authors: wang x. PLoS One. 2014 Oct 6;9(10):e108839. doi: 10.1371/journal.pone.0108839. eCollection 2014. PLoS One. 2014. PMID: 25286379 Free PMC article.

9

Proteasome Addiction Defined in Ewing Sarcoma Is Effectively Targeted by a Novel Class of 19S Proteasome Inhibitors.

Shukla N, Somwar R, Smith RS, Ambati S, Munoz S, Merchant M, D'Arcy P, Wang X, Kobos R, Antczak C, Bhinder B, Shum D, Radu C, Yang G, Taylor BS, Ng CK, Weigelt B, Khodos I, de Stanchina E, Reis-Filho JS, Ouerfelli O, Linder S, Djaballah H, Ladanyi M. Shukla N, et al. Among authors: wang x. Cancer Res. 2016 Aug 1;76(15):4525-34. doi: 10.1158/0008-5472.CAN-16-1040. Epub 2016 Jun 2. Cancer Res. 2016. PMID: 27256563 Free PMC article.

10

A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance.

Tian Z, D'Arcy P, Wang X, Ray A, Tai YT, Hu Y, Carrasco RD, Richardson P, Linder S, Chauhan D, Anderson KC. Tian Z, et al. Among authors: wang x. Blood. 2014 Jan 30;123(5):706-16. doi: 10.1182/blood-2013-05-500033. Epub 2013 Dec 6. Blood. 2014. PMID: 24319254 Free PMC article.

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