Wang W - Search Results

1

Excision repair of topoisomerase DNA-protein crosslinks (TOP-DPC).

Sun Y, Saha S, Wang W, Saha LK, Huang SN, Pommier Y. Sun Y, et al. Among authors: wang w. DNA Repair (Amst). 2020 May;89:102837. doi: 10.1016/j.dnarep.2020.102837. Epub 2020 Mar 7. DNA Repair (Amst). 2020. PMID: 32200233 Free PMC article. Review.

2

Tyrosyl-DNA Phosphodiesterase 1 and Topoisomerase I Activities as Predictive Indicators for Glioblastoma Susceptibility to Genotoxic Agents.

Wang W, Rodriguez-Silva M, Acanda de la Rocha AM, Wolf AL, Lai Y, Liu Y, Reinhold WC, Pommier Y, Chambers JW, Tse-Dinh YC. Wang W, et al. Cancers (Basel). 2019 Sep 23;11(10):1416. doi: 10.3390/cancers11101416. Cancers (Basel). 2019. PMID: 31547492 Free PMC article.

3

Recifin A, Initial Example of the Tyr-Lock Peptide Structural Family, Is a Selective Allosteric Inhibitor of Tyrosyl-DNA Phosphodiesterase I.

Krumpe LRH, Wilson BAP, Marchand C, Sunassee SN, Bermingham A, Wang W, Price E, Guszczynski T, Kelley JA, Gustafson KR, Pommier Y, Rosengren KJ, Schroeder CI, O'Keefe BR. Krumpe LRH, et al. Among authors: wang w. J Am Chem Soc. 2020 Dec 16;142(50):21178-21188. doi: 10.1021/jacs.0c10418. Epub 2020 Dec 2. J Am Chem Soc. 2020. PMID: 33263997 Free PMC article.

4

Discovery of 4-alkoxy-2-aryl-6,7-dimethoxyquinolines as a new class of topoisomerase I inhibitors endowed with potent in vitro anticancer activity.

Elbadawi MM, Eldehna WM, Wang W, Agama KK, Pommier Y, Abe M. Elbadawi MM, et al. Among authors: wang w. Eur J Med Chem. 2021 Apr 5;215:113261. doi: 10.1016/j.ejmech.2021.113261. Epub 2021 Feb 9. Eur J Med Chem. 2021. PMID: 33631697 Free PMC article.

5

The synthesis of furoquinolinedione and isoxazoloquinolinedione derivatives as selective Tyrosyl-DNA phosphodiesterase 2 (TDP2) inhibitors.

Yang H, Zhu XQ, Wang W, Chen Y, Hu Z, Zhang Y, Hu DX, Yu LM, Agama K, Pommier Y, An LK. Yang H, et al. Among authors: wang w. Bioorg Chem. 2021 Jun;111:104881. doi: 10.1016/j.bioorg.2021.104881. Epub 2021 Apr 1. Bioorg Chem. 2021. PMID: 33839584 Free PMC article.

6

Synthesis of Methoxy-, Methylenedioxy-, Hydroxy-, and Halo-Substituted Benzophenanthridinone Derivatives as DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Inhibitors and Their Biological Activity for Drug-Resistant Cancer.

Hu DX, Tang WL, Zhang Y, Yang H, Wang W, Agama K, Pommier Y, An LK. Hu DX, et al. Among authors: wang w. J Med Chem. 2021 Jun 10;64(11):7617-7629. doi: 10.1021/acs.jmedchem.1c00318. Epub 2021 May 19. J Med Chem. 2021. PMID: 34008967 Free PMC article.

7

Small molecule microarray identifies inhibitors of tyrosyl-DNA phosphodiesterase 1 that simultaneously access the catalytic pocket and two substrate binding sites.

Zhao XZ, Kiselev E, Lountos GT, Wang W, Tropea JE, Needle D, Hilimire TA, Schneekloth JS Jr, Waugh DS, Pommier Y, Burke TR Jr. Zhao XZ, et al. Among authors: wang w. Chem Sci. 2021 Jan 28;12(11):3876-3884. doi: 10.1039/d0sc05411a. Chem Sci. 2021. PMID: 34163656 Free PMC article.

8

PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation.

Sun Y, Chen J, Huang SN, Su YP, Wang W, Agama K, Saha S, Jenkins LM, Pascal JM, Pommier Y. Sun Y, et al. Among authors: wang w. Nat Commun. 2021 Aug 18;12(1):5010. doi: 10.1038/s41467-021-25252-9. Nat Commun. 2021. PMID: 34408146 Free PMC article.

9

Synthesis of 11-aminoalkoxy substituted benzophenanthridine derivatives as tyrosyl-DNA phosphodiesterase 1 inhibitors and their anticancer activity.

Yang H, Wang FT, Wu M, Wang W, Agama K, Pommier Y, An LK. Yang H, et al. Among authors: wang w, wang ft. Bioorg Chem. 2022 Jun;123:105789. doi: 10.1016/j.bioorg.2022.105789. Epub 2022 Apr 4. Bioorg Chem. 2022. PMID: 35429714 Free PMC article.

10

Phosphonic acid-containing inhibitors of tyrosyl-DNA phosphodiesterase 1.

Zhao XZ, Wang W, Lountos GT, Tropea JE, Needle D, Pommier Y, Burke TR Jr. Zhao XZ, et al. Among authors: wang w. Front Chem. 2022 Aug 16;10:910953. doi: 10.3389/fchem.2022.910953. eCollection 2022. Front Chem. 2022. PMID: 36051621 Free PMC article.

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