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Crystal structures of Babesia microti lactate dehydrogenase BmLDH reveal a critical role for Arg99 in catalysis.
Yu L, Shen Z, Liu Q, Zhan X, Luo X, An X, Sun Y, Li M, Wang S, Nie Z, Ao Y, Zhao Y, Peng G, Mamoun CB, He L, Zhao J. Yu L, et al. Among authors: wang s. FASEB J. 2019 Dec;33(12):13669-13682. doi: 10.1096/fj.201901259R. Epub 2019 Oct 4. FASEB J. 2019. PMID: 31585506
Interestingly, mutation of Arg99 to Ala had no impact on the overall structure and affinity of BmLDH to NADH but dramatically altered the closure of the enzyme's active pocket. Together, these structural and biochemical data highlight significant differences between B. mic …
Interestingly, mutation of Arg99 to Ala had no impact on the overall structure and affinity of BmLDH to NADH but dramatically altered the cl …
Inhibitory Effects of Fosmidomycin Against Babesia microti in vitro.
Wang S, Li M, Luo X, Yu L, Nie Z, Liu Q, An X, Ao Y, Liu Q, Chen J, Tian Y, Zhao J, He L. Wang S, et al. Front Cell Dev Biol. 2020 Apr 28;8:247. doi: 10.3389/fcell.2020.00247. eCollection 2020. Front Cell Dev Biol. 2020. PMID: 32411701 Free PMC article.
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