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Structure of GPR101-Gs enables identification of ligands with rejuvenating potential.
Yang Z, Wang JY, Yang F, Zhu KK, Wang GP, Guan Y, Ning SL, Lu Y, Li Y, Zhang C, Zheng Y, Zhou SH, Wang XW, Wang MW, Xiao P, Yi F, Zhang C, Zhang PJ, Xu F, Liu BH, Zhang H, Yu X, Gao N, Sun JP. Yang Z, et al. Among authors: wang jy, wang xw, wang mw, wang gp. Nat Chem Biol. 2024 Apr;20(4):484-492. doi: 10.1038/s41589-023-01456-6. Epub 2023 Nov 9. Nat Chem Biol. 2024. PMID: 37945893
Single hormone or synthetic agonist induces Gs/Gi coupling selectivity of EP receptors via distinct binding modes and propagating paths.
Huang SM, Xiong MY, Liu L, Mu J, Wang MW, Jia YL, Cai K, Tie L, Zhang C, Cao S, Wen X, Wang JL, Guo SC, Li Y, Qu CX, He QT, Cai BY, Xue C, Gan S, Xie Y, Cong X, Yang Z, Kong W, Li S, Li Z, Xiao P, Yang F, Yu X, Guan YF, Zhang X, Liu Z, Yang BX, Du Y, Sun JP. Huang SM, et al. Among authors: wang jl, wang mw. Proc Natl Acad Sci U S A. 2023 Jul 25;120(30):e2216329120. doi: 10.1073/pnas.2216329120. Epub 2023 Jul 21. Proc Natl Acad Sci U S A. 2023. PMID: 37478163 Free PMC article.
569 results