Wang L - Search Results

1

N-Benzyl Benzamide Derivatives as Selective Sub-Nanomolar Butyrylcholinesterase Inhibitors for Possible Treatment in Advanced Alzheimer's Disease.

Du C, Wang L, Guan Q, Yang H, Chen T, Liu Y, Li Q, Lyu W, Lu X, Chen Y, Liu Y, Liu H, Feng F, Liu W, Liu Z, Li W, Chen Y, Sun H. Du C, et al. Among authors: wang l. J Med Chem. 2022 Aug 25;65(16):11365-11387. doi: 10.1021/acs.jmedchem.2c00944. Epub 2022 Aug 15. J Med Chem. 2022. PMID: 35969197

2

Structure-based design and synthesis of small molecular inhibitors disturbing the interaction of MLL1-WDR5.

Li DD, Chen WL, Xu XL, Jiang F, Wang L, Xie YY, Zhang XJ, Guo XK, You QD, Sun HP. Li DD, et al. Among authors: wang l. Eur J Med Chem. 2016 Aug 8;118:1-8. doi: 10.1016/j.ejmech.2016.04.032. Epub 2016 Apr 13. Eur J Med Chem. 2016. PMID: 27116709

3

Novel Tetrahydropyrido[4,3-d]pyrimidines as Potent Inhibitors of Chaperone Heat Shock Protein 90.

Jiang F, Wang HJ, Jin YH, Zhang Q, Wang ZH, Jia JM, Liu F, Wang L, Bao QC, Li DD, You QD, Xu XL. Jiang F, et al. Among authors: wang zh, wang l, wang hj. J Med Chem. 2016 Dec 8;59(23):10498-10519. doi: 10.1021/acs.jmedchem.6b00912. Epub 2016 Nov 22. J Med Chem. 2016. PMID: 27933959

4

Structure-activity and structure-property relationships of novel Nrf2 activators with a 1,2,4-oxadiazole core and their therapeutic effects on acetaminophen (APAP)-induced acute liver injury.

Xu LL, Wu YF, Wang L, Li CC, Li L, Di B, You QD, Jiang ZY. Xu LL, et al. Among authors: wang l. Eur J Med Chem. 2018 Sep 5;157:1376-1394. doi: 10.1016/j.ejmech.2018.08.071. Epub 2018 Aug 28. Eur J Med Chem. 2018. PMID: 30196061

5

Discovery of novel diaryl urea derivatives bearing a triazole moiety as potential antitumor agents.

Qin M, Yan S, Wang L, Zhang H, Zhao Y, Wu S, Wu D, Gong P. Qin M, et al. Among authors: wang l. Eur J Med Chem. 2016 Jun 10;115:1-13. doi: 10.1016/j.ejmech.2016.02.071. Epub 2016 Mar 3. Eur J Med Chem. 2016. PMID: 26991938

6

Structure-based virtual screening and optimization of modulators targeting Hsp90-Cdc37 interaction.

Wang L, Li L, Zhou ZH, Jiang ZY, You QD, Xu XL. Wang L, et al. Eur J Med Chem. 2017 Aug 18;136:63-73. doi: 10.1016/j.ejmech.2017.04.074. Epub 2017 Apr 30. Eur J Med Chem. 2017. PMID: 28482218

7

Scaffold Hopping of Natural Product Evodiamine: Discovery of a Novel Antitumor Scaffold with Excellent Potency against Colon Cancer.

Wang L, Fang K, Cheng J, Li Y, Huang Y, Chen S, Dong G, Wu S, Sheng C. Wang L, et al. J Med Chem. 2020 Jan 23;63(2):696-713. doi: 10.1021/acs.jmedchem.9b01626. Epub 2020 Jan 10. J Med Chem. 2020. PMID: 31880942

8

Discovery of AZD4573, a Potent and Selective Inhibitor of CDK9 That Enables Short Duration of Target Engagement for the Treatment of Hematological Malignancies.

Barlaam B, Casella R, Cidado J, Cook C, De Savi C, Dishington A, Donald CS, Drew L, Ferguson AD, Ferguson D, Glossop S, Grebe T, Gu C, Hande S, Hawkins J, Hird AW, Holmes J, Horstick J, Jiang Y, Lamb ML, McGuire TM, Moore JE, O'Connell N, Pike A, Pike KG, Proia T, Roberts B, San Martin M, Sarkar U, Shao W, Stead D, Sumner N, Thakur K, Vasbinder MM, Varnes JG, Wang J, Wang L, Wu D, Wu L, Yang B, Yao T. Barlaam B, et al. Among authors: wang l, wang j. J Med Chem. 2020 Dec 24;63(24):15564-15590. doi: 10.1021/acs.jmedchem.0c01754. Epub 2020 Dec 11. J Med Chem. 2020. PMID: 33306391

9

Structure-based design and structure-activity relationships of 1,2,3,4-tetrahydroisoquinoline derivatives as potential PDE4 inhibitors.

Liao Y, Guo Y, Li S, Wang L, Tang Y, Li T, Chen W, Zhong G, Song G. Liao Y, et al. Among authors: wang l. Bioorg Med Chem Lett. 2018 Apr 15;28(7):1188-1193. doi: 10.1016/j.bmcl.2018.02.056. Epub 2018 Mar 6. Bioorg Med Chem Lett. 2018. PMID: 29545101

10

Targeting dihydrofolate reductase: Design, synthesis and biological evaluation of novel 6-substituted pyrrolo[2,3-d]pyrimidines as nonclassical antifolates and as potential antitumor agents.

Gao T, Zhang C, Shi X, Guo R, Zhang K, Gu J, Li L, Li S, Zheng Q, Cui M, Cui M, Gao X, Liu Y, Wang L. Gao T, et al. Among authors: wang l. Eur J Med Chem. 2019 Sep 15;178:329-340. doi: 10.1016/j.ejmech.2019.06.013. Epub 2019 Jun 6. Eur J Med Chem. 2019. PMID: 31200235

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