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CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors.
Wang H, Franco F, Tsui YC, Xie X, Trefny MP, Zappasodi R, Mohmood SR, Fernández-García J, Tsai CH, Schulze I, Picard F, Meylan E, Silverstein R, Goldberg I, Fendt SM, Wolchok JD, Merghoub T, Jandus C, Zippelius A, Ho PC. Wang H, et al. Nat Immunol. 2020 Mar;21(3):298-308. doi: 10.1038/s41590-019-0589-5. Epub 2020 Feb 17. Nat Immunol. 2020. PMID: 32066953 Free PMC article.
Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion.
Yu YR, Imrichova H, Wang H, Chao T, Xiao Z, Gao M, Rincon-Restrepo M, Franco F, Genolet R, Cheng WC, Jandus C, Coukos G, Jiang YF, Locasale JW, Zippelius A, Liu PS, Tang L, Bock C, Vannini N, Ho PC. Yu YR, et al. Among authors: wang h. Nat Immunol. 2020 Dec;21(12):1540-1551. doi: 10.1038/s41590-020-0793-3. Epub 2020 Oct 5. Nat Immunol. 2020. PMID: 33020660
Metabolic reprogramming of terminally exhausted CD8+ T cells by IL-10 enhances anti-tumor immunity.
Guo Y, Xie YQ, Gao M, Zhao Y, Franco F, Wenes M, Siddiqui I, Bevilacqua A, Wang H, Yang H, Feng B, Xie X, Sabatel CM, Tschumi B, Chaiboonchoe A, Wang Y, Li W, Xiao W, Held W, Romero P, Ho PC, Tang L. Guo Y, et al. Among authors: wang h, wang y. Nat Immunol. 2021 Jun;22(6):746-756. doi: 10.1038/s41590-021-00940-2. Epub 2021 May 24. Nat Immunol. 2021. PMID: 34031618 Free PMC article.
The transcription factor Rfx7 limits metabolism of NK cells and promotes their maintenance and immunity.
Castro W, Chelbi ST, Niogret C, Ramon-Barros C, Welten SPM, Osterheld K, Wang H, Rota G, Morgado L, Vivier E, Raeber ME, Boyman O, Delorenzi M, Barras D, Ho PC, Oxenius A, Guarda G. Castro W, et al. Among authors: wang h. Nat Immunol. 2018 Aug;19(8):809-820. doi: 10.1038/s41590-018-0144-9. Epub 2018 Jul 2. Nat Immunol. 2018. PMID: 29967452 Free PMC article.
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